Antibacterial potential of selected phytomolecules: An experimental study.
antibacterial
berberine
ex vivo study
piperine
resistance
rutin
zebrafish
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
11
03
2021
received:
15
12
2020
accepted:
27
04
2021
pubmed:
1
5
2021
medline:
1
10
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Antibiotic resistance is a snowballing international threat. Some of the antibiotics have lost their effectiveness due to overuse and underuse. Thus, there is an urgent need to tackle this global challenge, either by inhibiting the resistance mechanisms or by the development of new chemical entities. Thus, in the current study, the antibacterial activity of selected phytomolecules was investigated against bacterial strains, alone and in combination, with standard drugs. The antibacterial potential of these phytomolecules was explored using in vitro assays (microtiter assay, bacterial growth kinetics, percentage retardation of growth, and antimicrobial synergy study) and in vivo studies (zebrafish infection model). In vitro and in vivo studies have shown promising antibacterial effects against, both, Gram-positive and Gram-negative bacteria. Moreover, a cell viability assay also indicated the cytoprotective effect of these phytomolecules in combination with standard antibiotics (SABX). Thus, these phytomolecules could be a promising broad-spectrum antibacterial agent in combination with standard antibiotics.
Identifiants
pubmed: 33930208
doi: 10.1111/1348-0421.12890
doi:
Substances chimiques
Anti-Bacterial Agents
0
Phytochemicals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-332Informations de copyright
© 2021 Wiley Publishing Asia Pty Ltd.
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