Type 3 secretion system as an anti-Pseudomonal target.
Anti-virulence
PcrV vaccines
Pseudomonas aeruginosa
T3SS
T3SS inhibitors
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
14
02
2021
revised:
17
04
2021
accepted:
19
04
2021
pubmed:
1
5
2021
medline:
22
6
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence. This finding suggests that T3SS impairment may be an alternative for antimicrobial agents, allowing P. aeruginosa infections to be directly combated avoiding antimicrobial pressure on this and other microorganisms. To date, different approaches have been proposed, including T3SS inhibition, vaccination strategies, development of anti-T3SS antibodies and gene silencing.
Identifiants
pubmed: 33930424
pii: S0882-4010(21)00179-0
doi: 10.1016/j.micpath.2021.104907
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Type III Secretion Systems
0
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104907Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.