Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.

Antipsychotic Agents / chemistry Binding Sites Clozapine / chemistry Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Molecular Docking Simulation Oxidation-Reduction Oxidative Stress Protein Binding Protein Conformation Structure-Activity Relationship alpha-Macroglobulins / chemistry
Alpha-2-macroglobulin Clozapine Protein-ligand interaction

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Jul 2021
Historique:
received: 18 03 2021
revised: 23 04 2021
accepted: 24 04 2021
pubmed: 1 5 2021
medline: 27 7 2021
entrez: 30 4 2021
Statut: ppublish

Résumé

In this study, the interaction between clozapine, an atypical antipsychotic drug, and alpha-2-macroglobulin (α

Identifiants

DOI: 10.1016/j.ijbiomac.2021.04.155 PMID: 33930446
pubmed: 33930446
pii: S0141-8130(21)00928-4
doi: 10.1016/j.ijbiomac.2021.04.155
pii:
doi:

Substances chimiques

A2M protein, human 0
Antipsychotic Agents 0
alpha-Macroglobulins 0
Clozapine J60AR2IKIC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

502-512

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Miloš Šunderić (M)

Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia. Electronic address: milos@inep.co.rs.

Tamara Vasović (T)

Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.

Miloš Milčić (M)

Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.

Čedo Miljević (Č)

Institute of Mental Health, University of Belgrade - Faculty of Medicine, Milana Kašanina 3, 11000 Belgrade, Serbia.

Olgica Nedić (O)

Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

Milan R Nikolić (MR)

Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.

Nikola Gligorijević (N)

Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Antipsychotic clozapine binding to...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Clozapine › Antipsychotic clozapine binding to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Antipsychotic clozapine binding to...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Antipsychotic clozapine binding to...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Antipsychotic clozapine binding to...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Antipsychotic clozapine binding to...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Antipsychotic clozapine binding to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Macroglobulines › alpha-Macroglobulines › Antipsychotic clozapine binding to...