Pyruvate carboxylase and cancer progression.
Energy metabolism
Metastasis
Pyruvate carboxylase
Journal
Cancer & metabolism
ISSN: 2049-3002
Titre abrégé: Cancer Metab
Pays: England
ID NLM: 101607582
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
14
09
2020
accepted:
04
04
2021
entrez:
1
5
2021
pubmed:
2
5
2021
medline:
2
5
2021
Statut:
epublish
Résumé
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells. In breast cancer, PC activity is linked to pulmonary metastasis, potentially by providing the ability to utilize glucose, fatty acids, and glutamine metabolism as needed under varying conditions as cells metastasize. PC enzymatic activity appears to be of particular importance in cancer cells that are unable to utilize glutamine for anaplerosis. Moreover, PC activity also plays a role in lipid metabolism and protection from oxidative stress in cancer cells. Thus, PC activity may be essential to link energy substrate utilization with cancer progression and to enable the metabolic flexibility necessary for cell resilience to changing and adverse conditions during the metastatic process.
Identifiants
pubmed: 33931119
doi: 10.1186/s40170-021-00256-7
pii: 10.1186/s40170-021-00256-7
pmc: PMC8088034
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
20Subventions
Organisme : NCI NIH HHS
ID : R01 CA232589
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197627
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NIH HHS
ID : R35CA197627
Pays : United States
Organisme : NIH HHS
ID : R01CA232589
Pays : United States
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