Evidence for biological markers of tinnitus: A systematic review.

Biomarkers Humans Psychometrics Tinnitus
Biomarker Genetic Inflammation Oxidative stress Tinnitus

Journal

Progress in brain research
ISSN: 1875-7855
Titre abrégé: Prog Brain Res
Pays: Netherlands
ID NLM: 0376441

Informations de publication

Date de publication:
2021
Historique:
entrez: 1 5 2021
pubmed: 2 5 2021
medline: 25 11 2021
Statut: ppublish

Résumé

Subjective tinnitus is a phantom sound heard only by the affected person and may be a symptom of various diseases. Tinnitus diagnosis and monitoring is based on subjective audiometric and psychometric methods. This review aimed to synthesize evidence for tinnitus presence or its severity. We searched several electronic databases, citation searches of the included primary studies through Web of Science, and further hand searches. At least two authors performed all systematic review steps. Sixty-two records were included and were categorized according the biological variable. Evidence for possible tinnitus biomarkers come from oxidative stress, interleukins, steroids and neurotransmitters categories. We found conflicting evidence for full blood count, vitamins, lipid profile, neurotrophic factors, or inorganic ions. There was no evidence for an association between tinnitus and the remaining categories. The current review evidences that larger studies, with stricter exclusion criteria and powerful harmonized methodological design are needed. Protocol published on PROSPERO (CRD42017070998).

Identifiants

DOI: 10.1016/bs.pbr.2021.01.022 PMID: 33931188
pubmed: 33931188
pii: S0079-6123(21)00022-4
doi: 10.1016/bs.pbr.2021.01.022
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

345-398

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Haúla F Haider (HF)

ENT Department, Hospital Cuf Tejo-Nova Medical School, Lisbon, Portugal; CUF Academic and Research Medical Center, Lisbon, Portugal; Comprehensive Health Research Centre (CHRC), Lisbon, Portugal. Electronic address: hfhaider@gmail.com.

Derek J Hoare (DJ)

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Sara F Ribeiro (SF)

ENT Department, Hospital Cuf Tejo-Nova Medical School, Lisbon, Portugal; CUF Academic and Research Medical Center, Lisbon, Portugal.

Diogo Ribeiro (D)

ENT Department, Hospital Cuf Tejo-Nova Medical School, Lisbon, Portugal; CUF Academic and Research Medical Center, Lisbon, Portugal.

Helena Caria (H)

Deafness Research Group, BTR Unit, BioISI, Faculty of Sciences, University of Lisbon (FCUL), Portugal; ESS/IPS-Biomedical Sciences Department, School of Health, Polytechnic Institute of Setubal, Portugal.

Nuno Trigueiros (N)

ENT Department, Hospital Pedro Hispano, Matosinhos, Portugal.

Luís Miguel Borrego (LM)

Department of Immunology, Chronic Diseases Research Center (CEDOC), Faculty of Medical Sciences, NOVA Medical School, Lisbon, Portugal; Department of Immunoallergy, LUZ SAUDE, Hospital da Luz, Lisbon, Portugal.

Agnieszka J Szczepek (AJ)

Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Ana Luísa Papoila (AL)

Bioestatistics Department, Faculty of Medical Sciences, NOVA Medical School, Lisbon, Portugal.

Asma Elarbed (A)

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Maria da Luz Martins (M)

ENT Department, Hospital Cuf Tejo-Nova Medical School, Lisbon, Portugal; CUF Academic and Research Medical Center, Lisbon, Portugal.

João Paço (J)

ENT Department, Hospital Cuf Tejo-Nova Medical School, Lisbon, Portugal; CUF Academic and Research Medical Center, Lisbon, Portugal.

Magdalena Sereda (M)

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Evidence for biological markers of tinnitus: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evidence for biological markers of tinnitus: A...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Psychométrie › Evidence for biological markers of tinnitus: A...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Acouphène › Evidence for biological markers of tinnitus: A...