Parvovirus B19-associated graft failure after allogeneic hematopoietic stem cell transplantation.
allogeneic hematopoietic stem cell transplantation
graft failure
parvovirus B19 infection
Journal
Cancer reports (Hoboken, N.J.)
ISSN: 2573-8348
Titre abrégé: Cancer Rep (Hoboken)
Pays: United States
ID NLM: 101747728
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
25
02
2021
received:
18
11
2020
accepted:
30
03
2021
pubmed:
2
5
2021
medline:
25
3
2022
entrez:
1
5
2021
Statut:
ppublish
Résumé
Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the literature is limited. Two pediatric patients were diagnosed with PVB19 infection around the time of allo-HSCT graft failure. Both cases were secondary graft failure and required second allo-HSCT. There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo-HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo-HSCT graft failure.
Sections du résumé
BACKGROUND
Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the literature is limited.
CASE
Two pediatric patients were diagnosed with PVB19 infection around the time of allo-HSCT graft failure. Both cases were secondary graft failure and required second allo-HSCT.
CONCLUSION
There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo-HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo-HSCT graft failure.
Identifiants
pubmed: 33932151
doi: 10.1002/cnr2.1403
pmc: PMC8789606
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1403Informations de copyright
© 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.
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