The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction.
diabetic cardiomyopathy
heart
metabolic diseases
mitochondria
oxidative stress
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
31
12
2020
accepted:
18
03
2021
pubmed:
2
5
2021
medline:
11
8
2021
entrez:
1
5
2021
Statut:
ppublish
Résumé
Metabolic diseases (MetDs) embrace a series of pathologies characterized by abnormal body glucose usage. The known diseases included in this group are metabolic syndrome, prediabetes and diabetes mellitus types 1 and 2. All of them are chronic pathologies that present metabolic disturbances and are classified as multi-organ diseases. Cardiomyopathy has been extensively described in diabetic patients without overt macrovascular complications. The heart is severely damaged during the progression of the disease; in fact, diabetic cardiomyopathies are the main cause of death in MetDs. Insulin resistance, hyperglycaemia and increased free fatty acid metabolism promote cardiac damage through mitochondria. These organelles supply most of the energy that the heart needs to beat and to control essential cellular functions, including Ca
Identifiants
pubmed: 33932959
doi: 10.1113/JP279376
pmc: PMC8424986
mid: NIHMS1737539
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3477-3493Subventions
Organisme : NIH HHS
ID : R01HL093671
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137266
Pays : United States
Organisme : PICT
ID : 2015-3009
Organisme : PICT
ID : PS-1
Organisme : NHLBI NIH HHS
ID : R01 HL142864
Pays : United States
Organisme : NIH HHS
ID : R01HL142864
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122124
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093671
Pays : United States
Organisme : NIH HHS
ID : R01HL122124
Pays : United States
Organisme : CONICET
Organisme : NIH HHS
ID : R01HL137266
Pays : United States
Informations de copyright
© 2021 The Authors. The Journal of Physiology © 2021 The Physiological Society.
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