Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.

CD36 Antigens / genetics Gene Expression Regulation Genetic Variation Humans Obesity / blood Peptide YY / blood Polymorphism, Single Nucleotide
CD36 Fat taste Obesity Peptide-YY Polymorphism rs1761667

Journal

Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603

Informations de publication

Date de publication:
05 2021
Historique:
received: 11 07 2020
revised: 18 02 2021
accepted: 28 02 2021
pubmed: 3 5 2021
medline: 3 9 2021
entrez: 2 5 2021
Statut: ppublish

Résumé

Human beings are often driven to exhibit dietary preference according to their hedonic characteristics. Though previous studies proposed that the fat taste preference of an obese individual was associated with BMI, the perception of fat taste differs for every individual. The genetic variation among populations in taste receptor genes such as CD36 may be a contributing factor for this difference. Satiety peptides can also play a role in the regulation of fat taste perception. Generally, this hormone helps us to feel the sense of satiety. We have analysed the relationship among oro-gustatory perception of dietary lipids, salivary peptide-YY and genetic polymorphism in CD36. Oral fatty acid sensitivity analysis was performed by alternative forced choice method. Salivary peptide-YY concentration was analysed by ELISA and single nucleotide polymorphism (SNP) in CD36 gene was determined by Real-Time PCR experiments. We observed that the SNP at rs1761667 of CD36 and oral detection threshold for linoleic acid (LA) are associated with choice of food, lipid profiles, peptide-YY as well as adiposity parameters in obese population. Obese peoples had significantly low levels of peptide YY than people with BMI less than 25. These factors possibly play a role in preference for energy rich diets, development of obesity and associated complications. This study provides a solid foundation for understanding the alterations in the dietary fat intake and levels of peptide-YY, which are associated with polymorphism in fat taste receptor. This is the first report that shows a significant relationship between the satiety hormone level, SNP in CD36 gene and oral fat detection threshold in human subjects.

Sections du résumé

BACKGROUND & AIMS
Human beings are often driven to exhibit dietary preference according to their hedonic characteristics. Though previous studies proposed that the fat taste preference of an obese individual was associated with BMI, the perception of fat taste differs for every individual. The genetic variation among populations in taste receptor genes such as CD36 may be a contributing factor for this difference. Satiety peptides can also play a role in the regulation of fat taste perception. Generally, this hormone helps us to feel the sense of satiety.
METHODS
We have analysed the relationship among oro-gustatory perception of dietary lipids, salivary peptide-YY and genetic polymorphism in CD36. Oral fatty acid sensitivity analysis was performed by alternative forced choice method. Salivary peptide-YY concentration was analysed by ELISA and single nucleotide polymorphism (SNP) in CD36 gene was determined by Real-Time PCR experiments.
RESULTS
We observed that the SNP at rs1761667 of CD36 and oral detection threshold for linoleic acid (LA) are associated with choice of food, lipid profiles, peptide-YY as well as adiposity parameters in obese population. Obese peoples had significantly low levels of peptide YY than people with BMI less than 25. These factors possibly play a role in preference for energy rich diets, development of obesity and associated complications.
CONCLUSION
This study provides a solid foundation for understanding the alterations in the dietary fat intake and levels of peptide-YY, which are associated with polymorphism in fat taste receptor. This is the first report that shows a significant relationship between the satiety hormone level, SNP in CD36 gene and oral fat detection threshold in human subjects.

Identifiants

DOI: 10.1016/j.clnu.2021.02.044 PMID: 33933736
pubmed: 33933736
pii: S0261-5614(21)00133-3
doi: 10.1016/j.clnu.2021.02.044
pii:
doi:

Substances chimiques

CD36 Antigens 0
Peptide YY 106388-42-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2707-2715

Informations de copyright

Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no competing interests.

Auteurs

Muthuswamy Karthi (M)

Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu, 641046, India.

Shanmugamprema Deepankumar (S)

Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu, 641046, India.

Ponnusamy Vinithra (P)

Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu, 641046, India.

Subramanian Gowtham (S)

Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu, 641046, India.

Krishnan Vasanth (K)

Molecular Biology Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamilnadu, 641046, India.

Palanivelu Praveen Raj (P)

Department of Bariatric Surgery, GEM Hospital and Research Centre, Coimbatore, Tamilnadu, 641045, India.

Rajasekaran Senthilkumar (R)

Department of Diabetes and Endocrinology, PSG Hospitals, Coimbatore, Tamilnadu, 641004, India.

Subramaniam Selvakumar (S)

Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu, 641046, India. Electronic address: selvs20@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Récepteurs éboueurs › Récepteurs éboueurs de classe B › Antigènes CD36 › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Peptide YY › Single nucleotide polymorphism in CD36:...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Single nucleotide polymorphism in CD36:...