Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
received:
16
11
2020
accepted:
06
04
2021
revised:
22
03
2021
entrez:
2
5
2021
pubmed:
3
5
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Alzheimer's disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of Alzheimer associated neuropathological changes, and Alzheimer's disease occurrence within 14 years. Within a German community-based cohort, two polygenic risk scores (clinical Alzheimer's disease and Aβ
Identifiants
pubmed: 33934115
doi: 10.1038/s41398-021-01380-0
pii: 10.1038/s41398-021-01380-0
pmc: PMC8088439
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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