Dose intensity and treatment duration of bortezomib in transplant-ineligible newly diagnosed multiple myeloma.
Aged
Antineoplastic Agents
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Bortezomib
/ administration & dosage
Comorbidity
Disease Management
Drug Administration Schedule
Duration of Therapy
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Myeloma
/ diagnosis
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Treatment Outcome
bortezomib
dose intensity
front-line treatment
multiple myeloma
peripheral neuropathy
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
28
04
2021
received:
05
02
2021
accepted:
29
04
2021
pubmed:
3
5
2021
medline:
25
12
2021
entrez:
2
5
2021
Statut:
ppublish
Résumé
Bortezomib-related peripheral neuropathy (PN) affects a relevant proportion of multiple myeloma (MM) patients treated with melphalan, prednisone, and bortezomib (VMP). Empirical dose modifications have attempted to reduce toxicity without compromising efficacy. We retrospectively evaluated the dose-response and dose-toxicity relationships in 114 unselected untreated MM patients intended for treatment with VMP with subcutaneous bortezomib. Sixty-two patients (54%) completed the 9 scheduled cycles. Median treatment duration was 48 weeks (range 1-57), cumulative bortezomib dose was 41.8 mg/m Biweekly full-dose treatment in the first cycles has a major impact in depth of response. Depth of response, cumulative bortezomib dose, and treatment duration had an impact in prolongation of PFS.
Sections du résumé
BACKGROUND
BACKGROUND
Bortezomib-related peripheral neuropathy (PN) affects a relevant proportion of multiple myeloma (MM) patients treated with melphalan, prednisone, and bortezomib (VMP). Empirical dose modifications have attempted to reduce toxicity without compromising efficacy.
PATIENTS AND METHODS
METHODS
We retrospectively evaluated the dose-response and dose-toxicity relationships in 114 unselected untreated MM patients intended for treatment with VMP with subcutaneous bortezomib.
RESULTS
RESULTS
Sixty-two patients (54%) completed the 9 scheduled cycles. Median treatment duration was 48 weeks (range 1-57), cumulative bortezomib dose was 41.8 mg/m
CONCLUSIONS
CONCLUSIONS
Biweekly full-dose treatment in the first cycles has a major impact in depth of response. Depth of response, cumulative bortezomib dose, and treatment duration had an impact in prolongation of PFS.
Substances chimiques
Antineoplastic Agents
0
Bortezomib
69G8BD63PP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-254Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
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