In vivo confocal microscopy study of corneal nerve alterations in children and youths with Type 1 diabetes.
Type 1 diabetes
children and youths
corneal nerve plexus
in vivo confocal microscopy
neurodegeneration
Journal
Pediatric diabetes
ISSN: 1399-5448
Titre abrégé: Pediatr Diabetes
Pays: Denmark
ID NLM: 100939345
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
13
03
2021
received:
23
11
2020
accepted:
16
04
2021
pubmed:
3
5
2021
medline:
29
1
2022
entrez:
2
5
2021
Statut:
ppublish
Résumé
To determine whether children and youths with Type 1 diabetes (T1D) have early alterations of the corneal subbasal nerve plexus detectable with in vivo confocal microscopy (IVCM) and to investigate the role of longitudinally measured major risk factors for diabetes complications associated with these alterations. One hundred and fifty children and youths with T1D and 51 age-matched controls were enrolled and underwent IVCM. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal fiber total branch density (CTBD), and corneal fiber fractal dimension (CNFrD) were measured. Risk factors for diabetes complications (blood pressure, BMI, HbA1c, lipoproteins, urinary albumin-creatinine ratio) were recorded at IVCM and longitudinally since T1D onset. Unpaired t-test was used to compare variables between the groups. Multiple regression models were calculated using IVCM parameters as dependent variables and risk factors as independent variables. All IVCM parameters, except CTBD, were significantly lower in the T1D patients. Glycometabolic control (HbA1c, visit-to-visit HbA1c variability, and mean HbA1c), and blood pressure were inversely correlated with IVCM parameters. Multiple regression showed that part of the variability in CNFL, CNFD, CTBD, and CNFraD was explained by HbA1c, blood pressure percentiles and age at IVCM examination, independent of diabetes duration, BMI percentile and LDL cholesterol. Comparable results were obtained using the mean value of risk factors measured longitudinally since T1D onset. Early signs of corneal nerve degeneration were found in children and youths with T1D. Glycometabolic control and blood pressure were the major risk factors for these alterations.
Identifiants
pubmed: 33934464
doi: 10.1111/pedi.13219
pmc: PMC8360056
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
780-786Informations de copyright
© 2021 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.
Références
Ocul Surf. 2016 Oct;14(4):507-514
pubmed: 27555566
J Vis Exp. 2011 Jan 03;(47):
pubmed: 21248693
Diabetes Care. 2007 Oct;30(10):2608-12
pubmed: 17623821
Diabetologia. 1993 Feb;36(2):150-4
pubmed: 8458529
Diabet Med. 2013 May;30(5):630-1
pubmed: 23323870
Pediatrics. 2017 Sep;140(3):
pubmed: 28827377
PLoS One. 2017 Jul 18;12(7):e0180175
pubmed: 28719619
N Engl J Med. 2012 Mar 29;366(13):1227-39
pubmed: 22455417
Lancet Diabetes Endocrinol. 2015 Aug;3(8):653-63
pubmed: 26184671
Cornea. 2016 Jun;35(6):847-52
pubmed: 26845318
Diabetes Care. 2012 Apr;35(4):821-8
pubmed: 22323412
J Diabetes Investig. 2015 May;6(3):334-42
pubmed: 25969719
Pediatr Diabetes. 2018 Oct;19 Suppl 27:262-274
pubmed: 30079595
Exp Eye Res. 2003 May;76(5):521-42
pubmed: 12697417
Sci Rep. 2018 Jan 8;8(1):14
pubmed: 29311586
Diabetes Care. 2013 Oct;36(10):3187-94
pubmed: 23723354
Med Image Anal. 2011 Oct;15(5):738-47
pubmed: 21719344
J Diabetes Complications. 2017 Jun;31(6):1066-1073
pubmed: 28347694
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Diabetes Care. 2003 Mar;26(3):697-701
pubmed: 12610024
Pediatr Diabetes. 2021 Aug;22(5):780-786
pubmed: 33934464
Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):830-837
pubmed: 30811546
Diabetes Res Clin Pract. 2014 May;104(2):248-56
pubmed: 24629408
J Diabetes Investig. 2012 Mar 28;3(2):191-8
pubmed: 24843565
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):853-8
pubmed: 26943147
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1113-1118
pubmed: 29490348
Diabetologia. 2018 Aug;61(8):1856-1861
pubmed: 29869146
Diabetes Care. 2020 Jan;43(Suppl 1):S135-S151
pubmed: 31862754
J Clin Endocrinol Metab. 2016 Sep;101(9):3257-63
pubmed: 27186858
Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5636-40
pubmed: 26313299
Diabet Med. 2011 Oct;28(10):1261-7
pubmed: 21699561
Curr Pediatr Rep. 2015 Jun 1;3(2):177-186
pubmed: 26425403