Myelodysplastic syndromes and overlap syndromes.
Genomic
Hypoplastic MDS
Mutation
Myelodysplastic syndromes
Myelodysplastic/myeloproliferative neoplasms
Overlap syndromes
Journal
Blood research
ISSN: 2287-979X
Titre abrégé: Blood Res
Pays: Korea (South)
ID NLM: 101605247
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
18
01
2021
revised:
09
03
2021
accepted:
10
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological neoplasms characterized by ineffective hematopoiesis, morphologic dysplasia, and cytopenia. MDS overlap syndromes include various disorders, such as myelodysplastic/myeloproliferative neoplasms and hypoplastic MDS with aplastic anemia characteristics. MDS overlap syndromes share the characteristics of other diseases, which make differential diagnoses challenging. Advances in genomic studies have led to the discovery of frequent mutations in MDS and overlap syndromes; however, most of the mutations are not specific for the diagnosis of these diseases. The molecular characteristics of the overlap syndromes usually do not show a just "in-between" form but rather heterogeneous features. Established diagnostic criteria for these diseases based on clinical, morphologic, and laboratory features are still useful when combined with genomic data. It is expected that further studies for MDS and overlap syndromes will place emphasis on the roles of mutations as therapeutic targets and prognostic indicators.
Identifiants
pubmed: 33935036
pii: br.2021.2021010
doi: 10.5045/br.2021.2021010
pmc: PMC8094000
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
S51-S64Références
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