Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Parkinson’s disease
alpha-synuclein (SNCA)
cholesteroI
dopamine transporter (DAT)
dopamine uptake
early stage parkinsonism
galactoceramide
striatum
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
01
2021
accepted:
22
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson's disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular pathology of idiopathic and familial PD. Here, we tested whether DAT function in governing dopamine (DA) uptake and release is modified in a human-α-synuclein-overexpressing (
Identifiants
pubmed: 33935654
doi: 10.3389/fncel.2021.658244
pmc: PMC8081845
doi:
Types de publication
Journal Article
Langues
eng
Pagination
658244Subventions
Organisme : Medical Research Council
ID : MR/P007058/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : K-1003
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1003
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0808
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/D012910/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1103
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K013866/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : H-1102
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M024962/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : H-1301
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J004324/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/N50192X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0801
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1305
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700932
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400144
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N029453/1
Pays : United Kingdom
Organisme : Alzheimer's Society
ID : 182
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1504
Pays : United Kingdom
Organisme : Parkinson's UK
ID : H-1003
Pays : United Kingdom
Organisme : Parkinson's UK
ID : J-0901
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V013599/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0803
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Threlfell, Mohammadi, Ryan, Connor-Robson, Platt, Anand, Serres, Sharp, Bengoa-Vergniory, Wade-Martins, Ewing, Cragg and Brimblecombe.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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