Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies.
COVID-19
SARS-CoV-2
immunology
male reproduction
viral orchitis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
01
2021
accepted:
09
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-2019) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been an ongoing pandemic and worldwide public health emergency, having drawn a lot of attention around the world. The pathogenesis of COVID-19 is characterized by infecting angiotensin-converting enzyme 2 (ACE2)-expressing cells, including testis-specific cells, namely, Leydig, Sertoli, and spermatogenic cells, which are closely related to male reproduction. This leads to aberrant hyperactivation of the immune system generating damage to the infected organs. An impairment in testicular function through uncontrolled immune responses alerts more attention to male infertility. Meanwhile, the recent clinical data indicate that the infection of the human testis with SARS-CoV-2 may impair male germ cell development, leading to germ cell loss and higher immune cell infiltration. In this review, we investigated the evidence of male reproductive dysfunction associated with the infection with SARS-CoV-2 and its possible immunological explanations and clinical remedies.
Identifiants
pubmed: 33935803
doi: 10.3389/fphys.2021.651408
pmc: PMC8079781
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
651408Informations de copyright
Copyright © 2021 Xu, He, Zhang, Hu, Su, Fang, Peng, Fan, Liu, Zhao and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
BMJ. 2020 Feb 19;368:m606
pubmed: 32075786
Am J Physiol Endocrinol Metab. 2006 May;290(5):E856-63
pubmed: 16352669
Science. 2010 Feb 5;327(5966):656-61
pubmed: 20133564
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
J Reprod Immunol. 2009 Jul;81(1):44-54
pubmed: 19520436
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
Nat Rev Immunol. 2020 May;20(5):269-270
pubmed: 32273594
JAMA. 2020 Apr 21;323(15):1488-1494
pubmed: 32125362
J Reprod Immunol. 2013 Dec;100(2):146-56
pubmed: 24139314
Viruses. 2018 Apr 16;10(4):
pubmed: 29659541
Dev Biol. 2000 Apr 15;220(2):225-37
pubmed: 10753512
J Reprod Immunol. 2000 Oct-Nov;48(2):69-80
pubmed: 11011073
Hum Reprod. 2021 Feb 01;:
pubmed: 33522572
Adv Immunol. 2013;120:163-84
pubmed: 24070384
Cell Mol Immunol. 2021 Feb;18(2):487-489
pubmed: 33318629
Am J Nephrol. 2020;51(5):343-348
pubmed: 32229732
Andrologia. 2018 Dec;50(11):e13140
pubmed: 30569651
Endocrinology. 1993 Jul;133(1):389-96
pubmed: 8319585
Front Endocrinol (Lausanne). 2017 Nov 20;8:307
pubmed: 29250030
Cell Tissue Res. 2006 May;324(2):311-8
pubmed: 16432710
Nature. 2016 Dec 15;540(7633):438-442
pubmed: 27798603
Curr Med Chem. 2017;24(30):3231-3241
pubmed: 28413960
Lancet Infect Dis. 2019 Feb;19(2):177-184
pubmed: 30558994
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Biochemistry. 2006 Oct 24;45(42):12654-63
pubmed: 17042482
Front Immunol. 2019 Aug 14;10:1872
pubmed: 31474981
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
Endocrinology. 2004 Oct;145(10):4703-11
pubmed: 15231706
Hum Reprod Update. 2017 Nov 1;23(6):629-645
pubmed: 28961800
Cell Tissue Res. 2002 May;308(2):277-85
pubmed: 12037584
Am J Respir Crit Care Med. 2020 Sep 1;202(5):756-759
pubmed: 32663409
Cell. 2016 Dec 1;167(6):1511-1524.e10
pubmed: 27884405
J Reprod Immunol. 2013 Nov;100(1):20-9
pubmed: 23668923
Andrology. 2019 Sep;7(5):690-702
pubmed: 31207127
J Med Virol. 2021 Jan;93(1):456-462
pubmed: 32621617
J Endocrinol Invest. 2021 May;44(5):1091-1096
pubmed: 33040303
J Reprod Immunol. 2002 Oct-Nov;57(1-2):19-34
pubmed: 12385831
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
J Exp Med. 2013 Jul 29;210(8):1559-74
pubmed: 23825187
Andrology. 2021 Jan;9(1):10-18
pubmed: 32357288
J Cell Mol Med. 2020 Aug;24(16):9472-9477
pubmed: 32594644
BJU Int. 2006 Jan;97(1):138-41
pubmed: 16336344
J Immunol. 2015 Jun 1;194(11):5455-64
pubmed: 25917085
Hum Reprod Update. 2018 Jul 1;24(4):416-441
pubmed: 29648649
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
J Exp Med. 2009 Oct 26;206(11):2511-26
pubmed: 19822646
Reproduction. 2008 Sep;136(3):345-59
pubmed: 18515316
EClinicalMedicine. 2020 Nov;28:100604
pubmed: 33134901
Cell Mol Immunol. 2014 Sep;11(5):428-37
pubmed: 24954222
Lancet Infect Dis. 2020 Jun;20(6):697-706
pubmed: 32224310
Lancet. 2003 Jun 14;361(9374):2045-6
pubmed: 12814717
J Autoimmun. 2020 Jul;111:102452
pubmed: 32291137
J Immunol. 2011 May 1;186(9):5162-72
pubmed: 21441459
Front Endocrinol (Lausanne). 2019 Apr 16;10:224
pubmed: 31040821
JAMA Netw Open. 2020 May 1;3(5):e208292
pubmed: 32379329
Arthritis Res Ther. 2009;11(5):126
pubmed: 19804618
Sci Rep. 2016 Jan 18;6:19507
pubmed: 26776505
Reprod Biomed Online. 2021 Mar;42(3):589-594
pubmed: 33384268
Endocrinology. 1994 May;134(5):2079-87
pubmed: 8156908
J Clin Med. 2019 Jun 06;8(6):
pubmed: 31174315
Lancet. 2015 Sep 5;386(9997):995-1007
pubmed: 26049252
Nat Immunol. 2010 Oct;11(10):889-96
pubmed: 20856220
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
BMJ. 2020 Apr 21;369:m1443
pubmed: 32317267
Biol Reprod. 2006 Feb;74(2):410-6
pubmed: 16237152
Chin Med J (Engl). 2020 May 5;133(9):1039-1043
pubmed: 32118639
Reproduction. 2011 Feb;141(2):249-58
pubmed: 21109610
Hum Reprod. 2003 Oct;18(10):2089-92
pubmed: 14507826
Andrology. 2017 Jul;5(4):640-663
pubmed: 28622464
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508