Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents.
ascorbate
depression
glutamate
interleukin-6
magnetic resonance spectroscopy
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
12
2020
accepted:
26
02
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Animal models of stress and related conditions, including depression, have shown that elevated peripheral levels of inflammatory cytokines have downstream consequences on glutamate (Glu) in the brain. Although studies in human adults with depression have reported evidence of higher inflammation but lower Glu in the anterior cingulate cortex (ACC), the extent to which peripheral inflammation contributes to glutamatergic abnormalities in adolescents with depression is not well-understood. It is also unclear whether antioxidants, such as ascorbate (Asc), may buffer against the effects of inflammation on Glu metabolism. Fifty-five depressed adolescents were recruited in the present cross-sectional study and provided blood samples, from which we assayed pro-inflammatory cytokines, and underwent a short-TE proton magnetic spectroscopy scan at 3T, from which we estimated Glu and Asc in the dorsal ACC. In the 31 adolescents with usable cytokine and Glu data, we found that IL-6 was significantly positively associated with dorsal ACC Glu (β = 0.466 ± 0.199,
Identifiants
pubmed: 33935833
doi: 10.3389/fpsyt.2021.642976
pmc: PMC8081972
doi:
Types de publication
Journal Article
Langues
eng
Pagination
642976Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015891
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110683
Pays : United States
Informations de copyright
Copyright © 2021 Ho, Teresi, Segarra, Ojha, Walker, Gu, Spielman, Sacchet, Jiang, Rosenberg-Hasson, Maecker and Gotlib.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arch Gen Psychiatry. 2012 Feb;69(2):139-49
pubmed: 21969419
Neurochem Res. 2015 May;40(5):875-84
pubmed: 25701025
Neuropsychopharmacology. 2017 Nov;42(12):2434-2445
pubmed: 28553837
Front Hum Neurosci. 2020 Oct 19;14:585512
pubmed: 33192421
J Immunol. 2020 Jun 15;204(12):3425-3433
pubmed: 32376648
EJNMMI Res. 2018 Jul 3;8(1):57
pubmed: 29971587
BMC Neurol. 2009 Jun 12;9 Suppl 1:S3
pubmed: 19534732
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
J Nutr Biochem. 2020 Nov;85:108459
pubmed: 32745879
Transl Psychiatry. 2012 Dec 04;2:e199
pubmed: 23212583
JAMA Psychiatry. 2013 Jan;70(1):31-41
pubmed: 22945416
Transl Psychiatry. 2020 Apr 23;10(1):119
pubmed: 32327639
Psychol Med. 2003 Oct;33(7):1203-10
pubmed: 14580075
J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
pubmed: 9204677
Mol Psychiatry. 2020 Aug 17;:
pubmed: 32807846
J Neurosci Res. 2013 Dec;91(12):1609-17
pubmed: 23996657
J Am Acad Child Psychiatry. 1984 Mar;23(2):191-7
pubmed: 6715741
Neuropsychopharmacology. 2017 Jan;42(1):193-215
pubmed: 27629368
Psychosom Med. 2009 Feb;71(2):171-86
pubmed: 19188531
J Neurophysiol. 2002 Jul;88(1):475-86
pubmed: 12091569
Clin Psychol Sci. 2020 Jul;8(4):690-703
pubmed: 32724728
NMR Biomed. 2001 Jun;14(4):260-4
pubmed: 11410943
Scand J Clin Lab Invest. 2012 May;72(3):204-11
pubmed: 22283828
Transl Psychiatry. 2017 May 30;7(5):e1139
pubmed: 28556831
J Affect Disord. 2013 Sep 25;150(3):736-44
pubmed: 23870425
J Affect Disord. 2012 Aug;139(3):230-9
pubmed: 21872339
Lancet Psychiatry. 2018 Apr;5(4):339-347
pubmed: 29496589
BMC Neurosci. 2007 May 16;8:32
pubmed: 17506898
Handb Exp Pharmacol. 2009;(194):417-49
pubmed: 19655114
Curr Dir Psychol Sci. 2009 Aug 1;18(4):200-204
pubmed: 20161119
J Am Acad Child Adolesc Psychiatry. 2020 Jul;59(7):842-855
pubmed: 31676392
Nutrients. 2017 Jun 27;9(7):
pubmed: 28654017
Neuron. 2010 Sep 9;67(5):735-48
pubmed: 20826306
J Magn Reson Imaging. 2008 Aug;28(2):351-8
pubmed: 18666156
Brain Behav Immun. 2020 May;86:43-52
pubmed: 30822466
J Am Acad Child Adolesc Psychiatry. 2000 Oct;39(10):1208
pubmed: 11026169
Comp Med. 2009 Dec;59(6):517-26
pubmed: 20034426
Brain Behav Immun. 2019 Jan;75:200-207
pubmed: 30394311
Magn Reson Med. 1994 Apr;31(4):365-73
pubmed: 8208111
Neuroscience. 2007 Apr 14;145(4):1426-38
pubmed: 17049173
Nat Rev Immunol. 2016 Jan;16(1):22-34
pubmed: 26711676
Neurosci Lett. 2001 Feb 16;299(1-2):113-6
pubmed: 11166951
Neuroreport. 1990 Nov-Dec;1(3-4):194-6
pubmed: 1983355
J Child Adolesc Psychopharmacol. 2010 Dec;20(6):513-6
pubmed: 21186970
Psychiatry Res Neuroimaging. 2016 Jan 30;247:25-33
pubmed: 26651598
Am J Hum Biol. 2012 Nov-Dec;24(6):863-5
pubmed: 23042671
Neurosci Biobehav Rev. 2012 Jan;36(1):198-205
pubmed: 21672551
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13507-12
pubmed: 17679691
Neurosci Biobehav Rev. 2016 Nov;70:271-287
pubmed: 27461914
Magn Reson Med. 2018 Jan;79(1):41-47
pubmed: 28370458
Mol Psychiatry. 2019 Jul;24(7):952-964
pubmed: 30315224
Clin Psychol Sci. 2019 Jul;7(4):754-767
pubmed: 31341724
J Neuropsychiatry Clin Neurosci. 2011 Spring;23(2):121-5
pubmed: 21677237
Neurosci Biobehav Rev. 2018 Nov;94:219-237
pubmed: 30201219
Sci Rep. 2016 May 31;6:26996
pubmed: 27243383
J Anat. 2011 Jul;219(1):53-64
pubmed: 21250988
Curr Top Behav Neurosci. 2017;31:173-198
pubmed: 27830574