Fetal cardiac evaluation in HIV-positive women under HAART therapy in a Romanian hospital.
AIDS
HIV
antiretroviral therapy
fetal heart
pregnancy
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
04
12
2020
accepted:
05
01
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
Human immunodeficiency virus (HIV) is an RNA (ribonucleic acid) virus that causes acquired immunodeficiency syndrome (AIDS). This disease has a major socioeconomical impact. The aim of the present study was to assess the fetal heart structure and function in HIV-positive pregnant women on highly active antiretroviral therapy (HAART). This is a prospective study conducted between January, 2018 and December, 2019. The hearts of fetuses from 14 HIV-positive pregnant women on HAART were assessed. Statistically significant sex-related cardiac changes in HIV-exposed uninfected fetuses of pregnant women on HAART were found. A narrow aorta was detected in female fetuses and a smaller left ventricular transverse diameter in male fetuses. Overall, the myocardial performance index remained unaltered. The impact of antiretroviral therapy on fetal heart seems to be sex-related. Accurate and complete information about the risks and benefits of antiretroviral treatment and management strategies to improve fetal outcomes may also ensure better compliance of the mothers to this treatment.
Identifiants
pubmed: 33936263
doi: 10.3892/etm.2021.10038
pii: ETM-0-0-10038
pmc: PMC8082575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
606Informations de copyright
Copyright: © Ursache et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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