Acute Symptomatic Seizures in Critically Ill Children: Frequency, Etiology and Outcomes.
Acute symptomatic seizure
antiepileptic drug (AEDs)
critical ill children
Journal
Journal of pediatric neurosciences
ISSN: 1817-1745
Titre abrégé: J Pediatr Neurosci
Pays: India
ID NLM: 101273794
Informations de publication
Date de publication:
Historique:
received:
25
10
2019
revised:
15
01
2020
accepted:
28
03
2020
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
Critically ill individuals have an increased risk of acute symptomatic seizures secondary to systemic illnesses; unrecognized or untreated seizures can quickly convert into status epilepticus, which is associated with high morbidity and mortality. The aim of this study was to determine frequency, etiology, and outcome of seizures in critical ill children admitted in intensive care unit of a tertiary care hospital. Retrospective review of medical records of all children admitted in pediatric intensive care unit (PICU) of the Aga Khan University from January 2016 to December 2018 and who had a new-onset seizure irrespective of underlying diagnosis was carried out after ethical review committee approval. Data were collected on a structured proforma; it included demographic information as well as relevant clinical and outcome information. The data were analyzed on Statistical Package for the Social Sciences (SPSS) software program, version 19.0. The descriptive statistics frequency and percentage was computed for qualitative variable. Mean and standard deviation were computed for quantitative variable, and univariate analysis was performed. During the study period, a total 2053 patients were admitted in the PICU. One hundred six (5%) had seizure. Sixty-three (59.5%) were males. Meningitis 21 (20%), sepsis 21 (20%), complicated pneumonia 18 (17%) were the major primary diagnosis in these children. Mean age of the study population was 75 months (standard deviation [SD] ± 54.4) and 72 (68%) were <5 years of age, whereas 63 (59.5%) were males. The seizures lasted >10min in 10 (10%) and were associated with high had neurological deficit ( Infection was the most common etiology associated with a new-onset seizure in children admitted in our PICU. Seizures lasting for >10min were observed with high neurological deficit. We did not find any association of mortality with seizure duration.
Sections du résumé
BACKGROUND
BACKGROUND
Critically ill individuals have an increased risk of acute symptomatic seizures secondary to systemic illnesses; unrecognized or untreated seizures can quickly convert into status epilepticus, which is associated with high morbidity and mortality.
OBJECTIVE
OBJECTIVE
The aim of this study was to determine frequency, etiology, and outcome of seizures in critical ill children admitted in intensive care unit of a tertiary care hospital.
MATERIALS AND METHODS
METHODS
Retrospective review of medical records of all children admitted in pediatric intensive care unit (PICU) of the Aga Khan University from January 2016 to December 2018 and who had a new-onset seizure irrespective of underlying diagnosis was carried out after ethical review committee approval. Data were collected on a structured proforma; it included demographic information as well as relevant clinical and outcome information. The data were analyzed on Statistical Package for the Social Sciences (SPSS) software program, version 19.0. The descriptive statistics frequency and percentage was computed for qualitative variable. Mean and standard deviation were computed for quantitative variable, and univariate analysis was performed.
RESULTS
RESULTS
During the study period, a total 2053 patients were admitted in the PICU. One hundred six (5%) had seizure. Sixty-three (59.5%) were males. Meningitis 21 (20%), sepsis 21 (20%), complicated pneumonia 18 (17%) were the major primary diagnosis in these children. Mean age of the study population was 75 months (standard deviation [SD] ± 54.4) and 72 (68%) were <5 years of age, whereas 63 (59.5%) were males. The seizures lasted >10min in 10 (10%) and were associated with high had neurological deficit (
CONCLUSION
CONCLUSIONS
Infection was the most common etiology associated with a new-onset seizure in children admitted in our PICU. Seizures lasting for >10min were observed with high neurological deficit. We did not find any association of mortality with seizure duration.
Identifiants
pubmed: 33936301
doi: 10.4103/jpn.JPN_140_19
pii: JPN-15-375
pmc: PMC8078641
doi:
Types de publication
Journal Article
Langues
eng
Pagination
375-378Informations de copyright
Copyright: © 2021 Journal of Pediatric Neurosciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Epileptic Disord. 2006 Dec;8(4):277-84
pubmed: 17150441
Brain. 2014 May;137(Pt 5):1429-38
pubmed: 24595203
Turk J Pediatr. 2010 May-Jun;52(3):301-5
pubmed: 20718189
Neurology. 2013 Jul 23;81(4):383-91
pubmed: 23794680
J Trop Pediatr. 2016 Apr;62(2):94-100
pubmed: 26892503
Clin Neurophysiol. 2007 Aug;118(8):1660-70
pubmed: 17588812