Characterizing database granularity using SNOMED-CT hierarchy.


Journal

AMIA ... Annual Symposium proceedings. AMIA Symposium
ISSN: 1942-597X
Titre abrégé: AMIA Annu Symp Proc
Pays: United States
ID NLM: 101209213

Informations de publication

Date de publication:
2020
Historique:
entrez: 3 5 2021
pubmed: 4 5 2021
medline: 17 6 2021
Statut: epublish

Résumé

Multi-center observational studies require recognition and reconciliation of differences in patient representations arising from underlying populations, disparate coding practices and specifics of data capture. This leads to different granularity or detail of concepts representing the clinical facts. For researchers studying certain populations of interest, it is important to ensure that concepts at the right level are used for the definition of these populations. We studied the granularity of concepts within 22 data sources in the OHDSI network and calculated a composite granularity score for each dataset. Three alternative SNOMED-based approaches for such score showed consistency in classifying data sources into three levels of granularity (low, moderate and high), which correlated with the provenance of data and country of origin. However, they performed unsatisfactorily in ordering data sources within these groups and showed inconsistency for small data sources. Further studies on examining approaches to data source granularity are needed.

Identifiants

pubmed: 33936474
pii: 134_3416797
pmc: PMC8075504

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

983-992

Subventions

Organisme : NLM NIH HHS
ID : R01 LM006910
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM007079
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM009886
Pays : United States

Informations de copyright

©2020 AMIA - All rights reserved.

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Auteurs

Anna Ostropolets (A)

Columbia University, New York, NY, USA.

Christian Reich (C)

IQVIA, Cambridge, MA, USA.

Patrick Ryan (P)

Columbia University, New York, NY, USA.
Janssen Epidemiology Analytics, Janssen Research & Development, Titusville, NJ, USA.

Chunhua Weng (C)

Columbia University, New York, NY, USA.

Anthony Molinaro (A)

Janssen Epidemiology Analytics, Janssen Research & Development, Titusville, NJ, USA.

Frank DeFalco (F)

Janssen Epidemiology Analytics, Janssen Research & Development, Titusville, NJ, USA.

Jitendra Jonnagaddala (J)

University of New South Wales Sydney, Australia.

Siaw-Teng Liaw (ST)

University of New South Wales Sydney, Australia.

Hokyun Jeon (H)

Ajou University Graduate School of Medicine, Suwon, Gyeonggi-do, Republic of Korea.

Rae Woong Park (RW)

Ajou University Graduate School of Medicine, Suwon, Gyeonggi-do, Republic of Korea.

Matthew E Spotnitz (ME)

Columbia University, New York, NY, USA.

Karthik Natarajan (K)

Columbia University, New York, NY, USA.

George Argyriou (G)

IQVIA, Cambridge, MA, USA.

Kristin Kostka (K)

IQVIA, Cambridge, MA, USA.

Robert Miller (R)

Tufts Medical Center, Institute for Clinical Research and Health Policy Studies, Boston, MA, USA.

Andrew Williams (A)

Tufts Medical Center, Institute for Clinical Research and Health Policy Studies, Boston, MA, USA.

Evan Minty (E)

O'Brien Centre for Population Health, Faculty of Medicine, University of Calgary, Canada.

Jose Posada (J)

Stanford Center for Biomedical Informatics Research, Stanford, CA, USA.

George Hripcsak (G)

Columbia University, New York, NY, USA.
Medical Informatics Services, New York-Presbyterian Hospital, New York, NY, USA.

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Classifications MeSH