Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity.
Aspirin
/ pharmacology
Atherosclerosis
/ physiopathology
Blood Platelets
/ cytology
Cytokines
Endothelial Cells
/ drug effects
Extracellular Vesicles
/ drug effects
Healthy Volunteers
Humans
Inflammation
/ immunology
Monocytes
/ cytology
Plaque, Atherosclerotic
/ physiopathology
Platelet Activation
/ drug effects
Platelet Aggregation
/ physiology
Tumor Necrosis Factor-alpha
extracellular vesicles
monocyte/platelet aggregates
proteomics
vascular inflammation
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
08
06
2020
revised:
24
03
2021
accepted:
01
04
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are emerging as key players in different stages of atherosclerosis. Here we provide evidence that EVs released by mixed aggregates of monocytes and platelets in response to TNF-α display pro-inflammatory actions on endothelial cells and atherosclerotic plaques. Tempering platelet activation with Iloprost, Aspirin or a P2Y
Identifiants
pubmed: 33936566
doi: 10.1002/jev2.12084
pii: JEV212084
pmc: PMC8077084
doi:
Substances chimiques
Cytokines
0
Tumor Necrosis Factor-alpha
0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
12084Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 22235
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 101604/Z/13/Z
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
Références
BMC Genomics. 2012 Aug 01;13:357
pubmed: 22849433
Cell. 2019 Apr 4;177(2):428-445.e18
pubmed: 30951670
J Immunol. 2011 May 15;186(10):5543-7
pubmed: 21460209
Sci Rep. 2017 Aug 30;7(1):9954
pubmed: 28855621
Circ Heart Fail. 2013 Jan;6(1):127-35
pubmed: 23152489
Blood. 2011 Aug 25;118(8):2366-74
pubmed: 21700772
J Extracell Vesicles. 2021 Apr;10(6):12084
pubmed: 33936566
Front Cardiovasc Med. 2017 Nov 21;4:74
pubmed: 29209618
Atherosclerosis. 2011 Dec;219(2):734-6
pubmed: 21968316
J Immunol. 2017 Apr 1;198(7):2876-2885
pubmed: 28242648
Front Cardiovasc Med. 2018 Jan 22;5:2
pubmed: 29404342
Nat Med. 2003 Jan;9(1):61-7
pubmed: 12483207
J Proteomics. 2013 Apr 26;82:155-65
pubmed: 23429260
Thromb Haemost. 2008 Nov;100(5):878-85
pubmed: 18989533
JACC Basic Transl Sci. 2017 Dec 25;2(6):790-807
pubmed: 30062186
Arterioscler Thromb Vasc Biol. 2005 May;25(5):1065-70
pubmed: 15705928
J Intern Med. 2014 Feb;275(2):144-54
pubmed: 24118494
J Am Coll Cardiol. 1998 Feb;31(2):352-8
pubmed: 9462579
J Proteomics. 2012 Jun 6;75(10):2960-71
pubmed: 22197968
Pathophysiol Haemost Thromb. 2006;35(1-2):15-22
pubmed: 16855341
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):193-9
pubmed: 14615387
Eur Heart J. 2009 Dec;30(24):3048-54
pubmed: 19687162
Sci Rep. 2018 Jul 3;8(1):9987
pubmed: 29968812
J Am Coll Cardiol. 2008 Oct 14;52(16):1302-11
pubmed: 18929241
Front Pharmacol. 2019 Dec 17;10:1479
pubmed: 31920664
Sci Rep. 2014 Jun 10;4:5237
pubmed: 24913598
J Am Coll Cardiol. 1999 Nov 1;34(5):1420-6
pubmed: 10551687
J Thromb Haemost. 2018 Jul;16(7):1423-1436
pubmed: 29781099
Sci Rep. 2018 Jun 15;8(1):9209
pubmed: 29907817
Circulation. 2002 May 7;105(18):2166-71
pubmed: 11994250
Cardiovasc Res. 2020 Jan 1;116(1):202-210
pubmed: 30715163
Pulm Circ. 2013 Apr;3(2):329-40
pubmed: 24015332
Inflammation. 2019 Feb;42(1):290-305
pubmed: 30218321
Clin Pharmacol Ther. 2005 Nov;78(5):468-76
pubmed: 16321613
EMBO Mol Med. 2014 Jan;6(1):27-42
pubmed: 24357647
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Ann N Y Acad Sci. 2010 Oct;1207:11-7
pubmed: 20955420
Eur Heart J. 2013 Oct;34(39):3028-34
pubmed: 24014390
J Am Coll Cardiol. 2007 Feb 20;49(7):772-7
pubmed: 17306706
FASEB J. 2016 Sep;30(9):3097-106
pubmed: 27226520
J Microsc. 2004 Jul;215(Pt 1):100-10
pubmed: 15230881
J Extracell Vesicles. 2014 Aug 06;3:
pubmed: 25147646
Lancet. 2012 Mar 31;379(9822):1214-24
pubmed: 22421340
Nat Methods. 2009 May;6(5):359-62
pubmed: 19377485
J Thromb Haemost. 2009 Jun;7(6):1019-28
pubmed: 19548909
Circ Cardiovasc Genet. 2009 Aug;2(4):379-88
pubmed: 20031610
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):571-80
pubmed: 24371083
Int J Cardiol. 2018 May 15;259:213-215
pubmed: 29579604
Transfusion. 2015 Mar;55(3):507-21
pubmed: 25332113
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
Cell Signal. 2020 Nov;75:109751
pubmed: 32860954
Circ Res. 2017 May 12;120(10):1649-1657
pubmed: 28495995
Mol Cell Proteomics. 2013 Aug;12(8):2205-19
pubmed: 23660474
J Biol Chem. 1999 Nov 19;274(47):33179-82
pubmed: 10559185
Science. 2016 Apr 8;352(6282):242-6
pubmed: 26989197
Platelets. 2012;23(5):368-75
pubmed: 22671289
PLoS One. 2011;6(10):e25595
pubmed: 22022418
J Cell Mol Med. 2012 Nov;16(11):2777-88
pubmed: 22697268
Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2364-7
pubmed: 10521365
J Am Coll Cardiol. 2001 Oct;38(4):1002-6
pubmed: 11583872