The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer.
cell-free DNA
circulating tumor associated cells
clinical biomarkers detection
exosomes
liquid biopsy
lung cancer
tumor-educated platelets
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
11
2020
accepted:
19
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Liquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA, circulating micro-RNAs, tumor-derived exosomes, and tumor-educated platelets, providing an overview of future potential applicability in the clinical practice. While several biomarkers have shown exciting results, diagnostic performance and clinical applicability is still limited. The combination of different biomarkers, as well as their combination with other diagnostic tools show great promise, although further research is still required to define and validate the role of liquid biopsies in clinical practice.
Identifiants
pubmed: 33937034
doi: 10.3389/fonc.2021.634316
pmc: PMC8085425
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
634316Informations de copyright
Copyright © 2021 Freitas, Sousa, Machado, Serino, Santos, Cruz-Martins, Teixeira, Cunha, Pereira, Oliveira, Costa and Hespanhol.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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