Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in
Drosophila
Notch signaling
Suppressor of Hairless
hematopoiesis
phosphorylation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
01
2021
accepted:
25
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors within the DNA-binding domain. Earlier we found that a phospho-mimetic mutation of the
Identifiants
pubmed: 33937259
doi: 10.3389/fcell.2021.658820
pmc: PMC8079769
doi:
Types de publication
Journal Article
Langues
eng
Pagination
658820Informations de copyright
Copyright © 2021 Frankenreiter, Gahr, Schmid, Zimmermann, Deichsel, Hoffmeister, Turkiewicz, Borggrefe, Oswald and Nagel.
Déclaration de conflit d'intérêts
HS is currently employed at AstraZeneca. All research presented in this manuscript was completed before any commercial affiliations took place. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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