MicroRNA-210-3p Promotes Chondrogenic Differentiation and Inhibits Adipogenic Differentiation Correlated with HIF-3
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2020
revised:
05
03
2021
accepted:
29
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Cartilage injury of the knee joint is very common. Due to the limited self-healing ability of articular cartilage, osteoarthritis is very likely to occur if left untreated. Bone marrow mesenchymal stem cells (BMMSCs) are widely used in the study of cartilage injury due to their low immunity and good amplification ability, but they still have disadvantages, such as heterogeneous undifferentiated cells. MicroRNAs can regulate the chondrogenic differentiation ability of MSCs by inhibiting or promoting mRNA translation and degradation. In this research, we primarily investigated the effect of microRNA-210-3p (miR-210-3p) on chondrogenic and adipogenic differentiation of BMMSCs in vitro. Our results demonstrate that miR-210-3p promoted chondrogenic differentiation and inhibited adipogenic differentiation of rat BMMSCs, which was related to the HIF-3
Identifiants
pubmed: 33937412
doi: 10.1155/2021/6699910
pmc: PMC8055413
doi:
Substances chimiques
Hif3a protein, rat
0
MIRN210 microRNA, rat
0
MicroRNAs
0
RNA, Messenger
0
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6699910Informations de copyright
Copyright © 2021 Meng Yang et al.
Déclaration de conflit d'intérêts
The authors claim that they have no known competitive financial interests or personal relationship conflicts.
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