Quantifying the Spatiotemporal Influence of Acute Myocardial Ischemia on Volumetric Conduction Speeds.
Journal
Computing in cardiology
ISSN: 2325-8861
Titre abrégé: Comput Cardiol (2010)
Pays: United States
ID NLM: 101562329
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
Acute myocardial ischemia compromises the ordered electrical activation of the heart, however, because of sampling limitations, volumetric changes in activation have not been measured. We used a large-animal experimental model and high-resolution volumetric mapping to study the effects of ischemia on conduction speeds (CS) throughout the myocardium. We estimated CS and electrocardiographic changes (ST segments) and evaluated the spatial and temporal correlations between them across 11 controlled episodes. We found that ischemia induces significant conduction slowing, reducing the global median speed by 25 cm/s. Furthermore, there was a high
Identifiants
pubmed: 33937430
doi: 10.22489/cinc.2020.279
pmc: PMC8082333
mid: NIHMS1695017
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : F30 HL149327
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103545
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM136986
Pays : United States
Références
Physiol Meas. 2020 Feb 05;41(1):015002
pubmed: 31860892
SoftwareX. 2020 Jan-Jun;11:100454
pubmed: 32607406
IEEE Trans Biomed Eng. 2021 Mar 30;PP:
pubmed: 33784613
Am J Physiol. 1977 Sep;233(3):H329-45
pubmed: 333943
Card Electrophysiol Rev. 2002 Sep;6(3):204-8
pubmed: 12114839
Funct Imaging Model Heart. 2019 Jun;11504:37-45
pubmed: 31799512
IEEE Trans Biomed Eng. 1998 May;45(5):563-71
pubmed: 9581054
Comput Biol Med. 2015 Oct 1;65:229-42
pubmed: 25978869
J Electrocardiol. 2016 May-Jun;49(3):323-36
pubmed: 26947437