Familial hypercholesterolemia and statins in the COVID-19 era: Mitigating the risk of ischemic stroke.
COVID-19
LDL cholesterol
endothelial dysfunction
familial hypercholesterolemia
statins
stroke
Journal
eNeurologicalSci
ISSN: 2405-6502
Titre abrégé: eNeurologicalSci
Pays: Netherlands
ID NLM: 101667077
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
21
02
2021
revised:
18
04
2021
accepted:
25
04
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
ppublish
Résumé
There is a continuing need for research about the underlying mechanisms behind ischemic strokes in COVID-19 patients. Pre-existing endothelial dysfunction, especially if it is accompanied by a viral infection of the endothelial cells may present an important mechanism behind the immunothrombotic/thromboembolic complications of the COVID-19 illness. Here we emphasize that pharmacotherapy with statins could partly counteract such pathophysiological scenarios. Accordingly, using familial hypercholesterolemia (FH) as a pertinent example of a lifelong endothelial dysfunction, we aim to make the clinicians and consulting neurologists aware of statins as a possible adjuvant therapy in the context of an increased risk of ischemic stroke in patients with COVID-19. Based on recent clinical evidence, there is a need to encourage clinicians and consulting neurologists to continue or initiate effective statin treatment to prevent an ischemic stroke, particularly when they encounter a hypercholesterolemic COVID-19 patient with FH.
Identifiants
pubmed: 33937536
doi: 10.1016/j.ensci.2021.100344
pii: S2405-6502(21)00036-8
pmc: PMC8078044
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100344Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
AV, MK none. PTK has received lecture honoraria and/or travel fees from Amgen, Novartis, Raisio Group, and Sanofi.
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