Psychosis and Dandy-Walker syndrome: a case report and review of the literature.
cerebellar vermis
cerebral ventricles
psychotic disorders
schizophrenia
schizophrenia spectrum and other psychotic disorders
Journal
General psychiatry
ISSN: 2517-729X
Titre abrégé: Gen Psychiatr
Pays: England
ID NLM: 101735271
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
05
2020
revised:
21
02
2021
accepted:
02
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.
Identifiants
pubmed: 33937630
doi: 10.1136/gpsych-2020-100254
pii: gpsych-2020-100254
pmc: PMC8054076
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e100254Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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