Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study.

Journal

The Lancet regional health. Western Pacific
ISSN: 2666-6065
Titre abrégé: Lancet Reg Health West Pac
Pays: England
ID NLM: 101774968

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 16 12 2020
revised: 22 01 2021
accepted: 08 02 2021
entrez: 3 5 2021
pubmed: 4 5 2021
medline: 4 5 2021
Statut: ppublish

Résumé

In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few studies have assessed the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia. This study recruited participants presenting for COVID-19 testing at three Melbourne metropolitan hospitals during a period of low COVID-19 prevalence. The Abbott PanBio The specificity of the Abbott PanBio Given the high specificity, antigen-based tests may be most useful in rapidly triaging public health and hospital resources while expediting confirmatory RT-PCR testing. Considering the limitations in test sensitivity and the potential for rapid transmission in susceptible populations, particularly in hospital settings, careful consideration is required for implementation of antigen testing in a low prevalence setting. This work was funded by the Victorian Department of Health and Human Services. The funder was not involved in data analysis or manuscript preparation.

Sections du résumé

BACKGROUND BACKGROUND
In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few studies have assessed the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia.
METHODS METHODS
This study recruited participants presenting for COVID-19 testing at three Melbourne metropolitan hospitals during a period of low COVID-19 prevalence. The Abbott PanBio
FINDINGS RESULTS
The specificity of the Abbott PanBio
INTERPRETATION CONCLUSIONS
Given the high specificity, antigen-based tests may be most useful in rapidly triaging public health and hospital resources while expediting confirmatory RT-PCR testing. Considering the limitations in test sensitivity and the potential for rapid transmission in susceptible populations, particularly in hospital settings, careful consideration is required for implementation of antigen testing in a low prevalence setting.
FUNDING BACKGROUND
This work was funded by the Victorian Department of Health and Human Services. The funder was not involved in data analysis or manuscript preparation.

Identifiants

DOI: 10.1016/j.lanwpc.2021.100115 PMID: 33937887 PMC: PMC8076656
pubmed: 33937887
doi: 10.1016/j.lanwpc.2021.100115
pii: S2666-6065(21)00024-9
pmc: PMC8076656
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100115

Informations de copyright

© 2021 The Author(s). Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

SL reports grants from National Institutes of Health (NIH), grants from American Foundation for AIDS Research (amfAR), grants from Gilead Sciences, grants from Merck, grants from ViiV, grants from Leidos, grants from Wellcome Trust, grants from Australian Centre for HIV and Hepatitis Virology Research (ACH2), grants from Melbourne HIV Cure Consortium, grants from Victorian Department of Health and Human Services (DHHS), grants from Medical Research Future Fund (MRFF), outside the submitted work. KG reports grants from Royal Australasian Society of Physicians (RACP), grants from Murdoch Children's Research Institute (MCRI), other from Isabel & John Gilbertson Charitable Trust, grants from Department of Health and Human Services (DHHS) Victoria, outside the submitted work.

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Auteurs

Stephen Muhi (S)

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia.
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Nick Tayler (N)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Emergency Medicine, Royal Melbourne Hospital, Melbourne, Australia.

Tuyet Hoang (T)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Susan A Ballard (SA)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Maryza Graham (M)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Microbiology, Monash Health, Melbourne, Australia.

Amanda Rojek (A)

Department of Emergency Medicine, Royal Melbourne Hospital, Melbourne, Australia.

Jason C Kwong (JC)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

Jason A Trubiano (JA)

Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

Olivia Smibert (O)

Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

George Drewett (G)

Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

Fiona James (F)

Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

Emma Gardiner (E)

Department of Emergency Medicine, Royal Melbourne Hospital, Melbourne, Australia.

Socheata Chea (S)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Nicole Isles (N)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Michelle Sait (M)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Shivani Pasricha (S)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

George Taiaroa (G)

Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Julie McAuley (J)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Eloise Williams (E)

Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia.

Katherine B Gibney (KB)

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia.
Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infectious Diseases and Immunity, Melbourne, Australia.

Timothy P Stinear (TP)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.

Katherine Bond (K)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia.

Sharon R Lewin (SR)

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia.
Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infectious Diseases and Immunity, Melbourne, Australia.
Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.

Mark Putland (M)

Department of Emergency Medicine, Royal Melbourne Hospital, Melbourne, Australia.

Benjamin P Howden (BP)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Infectious Diseases, Austin Hospital, Melbourne, Australia.

Deborah A Williamson (DA)

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Australia.
Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia.

Classifications MeSH