Non-selective COX inhibitors impair memory formation and short-term but not long-term synaptic plasticity.
Animals
Aspirin
/ administration & dosage
Cyclooxygenase Inhibitors
/ administration & dosage
Dose-Response Relationship, Drug
Hippocampus
/ drug effects
Long-Term Potentiation
/ drug effects
Male
Maze Learning
/ drug effects
Neuronal Plasticity
/ drug effects
Rats
Rats, Wistar
Sodium Salicylate
/ administration & dosage
Spatial Learning
/ drug effects
Spatial Memory
/ drug effects
Acetylsalicylic acid
Cyclooxygenase
Learning and memory
Sodium salicylate
Synaptic plasticity
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
05
01
2021
accepted:
12
04
2021
pubmed:
4
5
2021
medline:
11
1
2022
entrez:
3
5
2021
Statut:
ppublish
Résumé
Cyclooxygenase (COX) plays a critical role in synaptic plasticity. Therefore, long-term administration of acetylsalicylic acid (ASA) and its main metabolite, salicylate, as a COX inhibitor may impair synaptic plasticity and subsequently memory formation. Although different studies have tried to explain the effects of ASA and sodium salicylate (SS) on learning and memory, the results are contradictory and the mechanisms are not exactly known. The present study was designed to investigate the effects of long-term low-dose (equivalent to prophylactic dose) and short-term high-dose (equivalent to analgesic dose) administration of ASA and SS respectively, on spatial learning and memory and hippocampal synaptic plasticity. Animals were treated with a low dose of ASA (2 mg/ml solvated in drinking water, 6 weeks) or a high dose of SS, a metabolite of ASA, (300 mg/kg, 3 days, twice-daily, i.p). Spatial memory and synaptic plasticity were assessed by water maze performance and in vivo field potential recording from CA1, respectively. Animals treated with ASA but not SS showed a significant increase in escape latency and distance moved. Furthermore, in the probe test, animals treated with both drugs spent less time in the target quadrant zone. The paired-pulse ratio (PPR) at 20-ms inter-pulse intervals (IPI) as an index of short-term plasticity in both treated groups was significantly higher than of the control group. Interestingly, none of the administered drugs affected long-term potentiation (LTP). These data suggested that long-term inhibition of COX disrupted memory acquisition and retrieval. Interestingly, cognitive impairments happened along with short-term but not long-term synaptic plasticity disturbance.
Identifiants
pubmed: 33937935
doi: 10.1007/s00210-021-02092-4
pii: 10.1007/s00210-021-02092-4
doi:
Substances chimiques
Cyclooxygenase Inhibitors
0
Aspirin
R16CO5Y76E
Sodium Salicylate
WIQ1H85SYP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1879-1891Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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