Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.
APOE ε4
Life's Simple 7
cardiovascular health
dementia
epidemiology
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
24
02
2021
received:
07
10
2020
accepted:
05
04
2021
pubmed:
4
5
2021
medline:
11
2
2022
entrez:
3
5
2021
Statut:
ppublish
Résumé
There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population. Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models. Among 1987 subjects, 291 incident cases of dementia were identified over a median follow-up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0.91), respectively. These results were significant in apolipoprotein E genotype ε4 (APOE ε4) allele non-carriers but not in carriers. Higher LS7 scores are protective for dementia, especially among the APOE ε4 noncarriers.
Identifiants
pubmed: 33938146
doi: 10.1002/alz.12359
pmc: PMC8560654
mid: NIHMS1730217
doi:
Substances chimiques
ApoE protein, human
0
Apolipoprotein E4
0
Apolipoproteins E
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1905-1913Subventions
Organisme : NIA NIH HHS
ID : R56 AG060156
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG066107
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG007232
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072474
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054080
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059013
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052410
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061008
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064614
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037212
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Informations de copyright
© 2021 the Alzheimer's Association.
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