Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia.

Adaptor Proteins, Signal Transducing / genetics Hepatocytes / metabolism Homozygous Familial Hypercholesterolemia Humans Hypercholesterolemia / genetics Induced Pluripotent Stem Cells / metabolism Receptors, LDL / genetics
LDL uptake LDLRAP1 autosomal recessive hypercholesterolemia disease modeling hepatocyte-like cells induced pluripotent stem cell

Journal

Stem cells and development
ISSN: 1557-8534
Titre abrégé: Stem Cells Dev
Pays: United States
ID NLM: 101197107

Informations de publication

Date de publication:
15 07 2021
Historique:
pubmed: 4 5 2021
medline: 22 3 2022
entrez: 3 5 2021
Statut: ppublish

Résumé

Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder caused by pathogenic variants in the low-density lipoprotein receptor (LDLR) adaptor protein 1 (

Identifiants

DOI: 10.1089/scd.2020.0199 PMID: 33938231
pubmed: 33938231
doi: 10.1089/scd.2020.0199
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Receptors, LDL 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

714-724

Auteurs

Parisa Nikasa (P)

Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Institute, Department of Development and Regeneration, University of Leuven (KULeuven), Leuven, Belgium.
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Tine Tricot (T)

Stem Cell Institute, Department of Development and Regeneration, University of Leuven (KULeuven), Leuven, Belgium.

Nejat Mahdieh (N)

Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Hossein Baharvand (H)

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran.
ORCID: 0000-0001-6528-3687

Mehdi Totonchi (M)

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Mohammad Saeid Hejazi (MS)

Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Catherine M Verfaillie (CM)

Stem Cell Institute, Department of Development and Regeneration, University of Leuven (KULeuven), Leuven, Belgium.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme lipidique › Hyperlipoprotéinémie de type II › Hypercholestérolémie familiale homozygote › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Hypercholestérolémie › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Patient-Specific Induced Pluripotent Stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Patient-Specific Induced Pluripotent Stem...