Effect of glucoglycyrrhizin on IgE-mediated immediate hypersensitivity in mice.
Anti-glycyrrhetinic acid monoclonal antibody (6D6)
Glucoglycyrrhizin (GGL)
Glycyrrhetinic acid (GA)
Glycyrrhizin (GL)
Passive cutaneous anaphylaxis
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
26
03
2021
accepted:
21
04
2021
pubmed:
4
5
2021
medline:
26
11
2021
entrez:
3
5
2021
Statut:
ppublish
Résumé
To evaluate the pharmacological property of glucoglycyrrhizin (GGL), a unique glycoside of glycyrrhetinic acid (GA), we investigated the anti-allergic effect of GGL on IgE-mediated immediate hypersensitivity in mice. GGL exhibited the antiallergic effect against IgE-mediated immediate hypersensitivity. At a dose of 100 mg/kg, GGL exhibited antiallergic activity equivalent to that of glycyrrhizin (GL). Furthermore, the pretreatment with anti-GA monoclonal antibody eliminated the antiallergic action of GGL. These results indicated that GGL may act in the same way as GL in the human body. Its safety should be verified for its use as a drug similar to GL.
Identifiants
pubmed: 33939081
doi: 10.1007/s11418-021-01523-z
pii: 10.1007/s11418-021-01523-z
doi:
Substances chimiques
Anti-Allergic Agents
0
Immunoglobulin E
37341-29-0
Glycyrrhizic Acid
6FO62043WK
Glycyrrhetinic Acid
P540XA09DR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
994-997Informations de copyright
© 2021. The Japanese Society of Pharmacognosy.
Références
Hayashi H, Fujii I, Iinuma M, Shibano M, Ozaki K, Watanabe H (2013) Characterization of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis. Biol Pharm Bull 36:1448–1453
doi: 10.1248/bpb.b13-00164
Finney RS, Somers GF (1958) The anti-inflammatory activity of glycyrrhetinic acid and derivatives. J Pharm Pharmacol 10:613–620
doi: 10.1111/j.2042-7158.1958.tb10349.x
Shibata S (2000) A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120:849–862
doi: 10.1248/yakushi1947.120.10_849
Baltina LA (2003) Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine. Curr Med Chem 10:155–171
doi: 10.2174/0929867033368538
Raphael TJ, Kuttan G (2003) Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine 10:483–489
doi: 10.1078/094471103322331421
Ram A, Mabalirajan U, Das M, Bhattacharya I, Dinda AK, Gangal SV, Ghosh B (2006) Glycyrrhizin alleviates experimental allergic asthma in mice. Int Immunopharmacol 6:1468–1477
doi: 10.1016/j.intimp.2006.04.020
Ma C, Ma Z, Liao XL, Liu J, Fu Q, Ma S (2013) Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+) CD25(+) Foxp3(+) regulatory T cells in ovalbumin-sensitized mice. J Ethnopharmacol 148:755–762
doi: 10.1016/j.jep.2013.04.021
Tsuge A, Hisaka S, Hayashi H, Nose M (2020) Effect of hot water extract of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis on contact hypersensitivity in mice. J Nat Med 74:415–420
doi: 10.1007/s11418-019-01386-5
Hisaka S, Murase S, Kishi H, Nose M (2021) I Immunological validation of the pharmacological and anti-allergic action of glycyrrhetinic acid from Glycyrrhizae Radix. Trad Kampo Med. https://doi.org/10.1002/tkm2.1278 (First published: 25 March 2021)
doi: 10.1002/tkm2.1278
Nose M, Tsutsui R, Hisaka S, Akiyama H, Inui T, Kawano N, Hayashi S, Hishida A, Fuchino H, Kudo T, Kawahara N, Yoshimatsu K (2020) Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems III: anti-allergic effects of hot water extracts on IgE-mediated immediate hypersensitivity in mice. J Nat Med 74:463–466
doi: 10.1007/s11418-019-01378-5
Tatsumi T, Yamada T, Nagai H, Terasawa K, Tani T, Nunome S, Saiki I (2001) A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacy. Biol Pharm Bull 24:284–290
doi: 10.1248/bpb.24.284
Yamamoto Y, Majima T, Saiki I, Tani T (2003) Pharmaceutical evaluation of Glycyrrhiza uralensis roots cultivated in eastern Nei-Meng-Gu of China. Biol Pharm Bull 26:1144–1149
doi: 10.1248/bpb.26.1144
Han S, Sun L, He F, Che H (2017) Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells. Sci Rep 7:7222
doi: 10.1038/s41598-017-07833-1
Akao T, Hayashi T, Kobashi K, Kanaoka M, Kato H, Kobayashi M, Takeda S, Oyama T (1994) Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats. J Pharm Pharmacol 46:135–137
doi: 10.1111/j.2042-7158.1994.tb03756.x
Takeda S, Ishihara K, Wakui Y, Amagaya S, Maruno M, Akao T, Kobashi K (1996) Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis. J Pharm Pharmacol 48:902–905
doi: 10.1111/j.2042-7158.1996.tb05998.x
Nose M, Ito M, Kamimura K, Shimizu M, Ogihara Y (1994) A comparison of the antihepatotoxic activity between glycyrrhizin and glycyrrhetinic acid. Planta Med 60:136–139
doi: 10.1055/s-2006-959435