The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks.
CAD
CZT
Myocardial blood flow
Myocardial flow reserve
Myocardial ischemia
SPECT
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
11
09
2020
accepted:
29
03
2021
revised:
29
03
2021
pubmed:
4
5
2021
medline:
14
1
2023
entrez:
3
5
2021
Statut:
ppublish
Résumé
Cardiac PET-derived measurements of myocardial blood flow (MBF) and myocardial flow reserve (MFR) are proven robust indexes of the severity of coronary artery disease (CAD). They facilitate the diagnosis of diffuse epicardial and microvascular disease and are also of prognostic significance. However, low availability and high cost have limited their wide clinical implementation. Over the last 15 years, cadmium zinc telluride (CZT)-based detectors have been implemented into SPECT imaging devices. Myocardial perfusion scintigraphy can be performed faster and with less radiation exposure as compared with standard gamma cameras. Rapid dynamic SPECT studies with higher count rates can be performed. This technological breakthrough has renewed the interest in SPECT MBF assessment in patients with CAD. Currently, two cardiac-centered CZT gamma cameras are available commercially-Discovery NM530c and D-SPECT. They differ in parameters such as collimator design, number of detectors, sensitivity, spatial resolution and image reconstruction. A number of publications have focused on the feasibility of dynamic CZT SPECT and on the correlation with cardiac PET and invasive coronary angiography measurements of fractional flow reserve. Current study reviews the present status of MBF and MFR assessment with CZT SPECT. It also aims to provide an overview of specific issues related to acquisition, processing and interpretation of quantitative studies in patients with CAD.
Identifiants
pubmed: 33939162
doi: 10.1007/s12350-021-02620-y
pii: 10.1007/s12350-021-02620-y
doi:
Substances chimiques
CdZnTe
0
Cadmium
00BH33GNGH
Tellurium
NQA0O090ZJ
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3137-3151Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. American Society of Nuclear Cardiology.
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