cIAP1/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro.
IAP family
NSCLC
apoptosis
birinapant
radiosensitive
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
03 May 2021
03 May 2021
Historique:
revised:
07
03
2021
received:
26
09
2020
accepted:
24
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
4
5
2021
Statut:
aheadofprint
Résumé
Tumour radioresistance is a major problem for cancer radiation therapy. To identify the underlying mechanisms of this resistance, we used human non-small cell lung cancer (NSCLC) cell lines and focused on the Inhibitor of Apoptosis Protein (IAP) family, which contributes to tumourigenesis and chemoresistance. We investigated the possible correlation between radioresistance in six NSCLC cell lines and IAP protein levels and tested the radiosensitizing effect of birinapant in vitro, a molecule that mimics the second mitochondria-derived activator of caspase. We found that birinapant-induced apoptosis and inhibited the proliferation of NSCLC cells after exposure to radiation. These effects were induced by birinapant downregulation of cIAP protein levels and changes of cIAP gene expression. Overall, birinapant can inhibit tumour growth of NSCLC cell lines to ironizing radiation and act as a promising strategy to overcome radioresistance in NSCLC.
Identifiants
pubmed: 33939305
doi: 10.1111/jcmm.16526
pmc: PMC8366455
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31670859
Organisme : National Natural Science Foundation of China
ID : 31971168
Organisme : National Natural Science Foundation of China
ID : 31800703
Organisme : National Natural Science Foundation of China
ID : 31900889
Organisme : CAMS Innovation Fund for MedicalScience
ID : 2017-I2M-1-016
Organisme : China Postdoctoral Science Foundation
ID : 2018M630106
Organisme : Key Research and Development (R&D) Projects of Shanxi Province
ID : 201903D321115
Organisme : State Key Laboratory of Microbial Technology Open Projects Fund
ID : M2020-07
Organisme : Key R&D Program of Shandong Province
ID : 2019GSF107056
Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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