The epigenetic regulation of synaptic genes contributes to the etiology of autism.
autism
epigenetic mechanisms
methylation
synaptic proteins
Journal
Reviews in the neurosciences
ISSN: 2191-0200
Titre abrégé: Rev Neurosci
Pays: Germany
ID NLM: 8711016
Informations de publication
Date de publication:
25 11 2021
25 11 2021
Historique:
received:
26
01
2021
accepted:
12
04
2021
pubmed:
4
5
2021
medline:
15
12
2021
entrez:
3
5
2021
Statut:
epublish
Résumé
Epigenetic mechanisms greatly affect the developing brain, as well as the maturation of synapses with pervasive, long-lasting consequences on behavior in adults. Substantial evidence exists that implicates dysregulation of epigenetic mechanisms in the etiology of neurodevelopmental disorders. Therefore, this review explains the role of enzymes involved in DNA methylation and demethylation in neurodevelopment by emphasizing changes of synaptic genes and proteins. Epigenetic causes of sex-dependent differences in the brain are analyzed in conjunction with the pathophysiology of autism spectrum disorders. Special attention is devoted to the epigenetic regulation of the melanoma-associated antigen-like gene 2 (
Identifiants
pubmed: 33939901
pii: revneuro-2021-0014
doi: 10.1515/revneuro-2021-0014
doi:
Substances chimiques
MAGEL2 protein, human
0
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-802Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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