A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan.
Active components
Bioactivity contribution
Huang-Qin Decoction
Irinotecan
Toxicity attenuating and efficacy enhancing
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
05
05
2020
entrez:
4
5
2021
pubmed:
5
5
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11. First, the potential bioactive constituents were obtained through system pharmacology strategy. Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration, TNF-α release of THP-1-derived macrophage and MTT assay in HCT116 cell. The contribution of each constituent in HQD was evaluated using the bioactive index E
Identifiants
pubmed: 33941341
pii: S1875-5364(21)60034-1
doi: 10.1016/S1875-5364(21)60034-1
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drugs, Chinese Herbal
0
Irinotecan
7673326042
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-375Informations de copyright
Copyright © 2021 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.