Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.
Amphiregulin
/ genetics
Animals
Cell Proliferation
/ drug effects
Endothelial Cells
/ metabolism
Female
Fibroblasts
/ drug effects
Humans
Lymphangiogenesis
/ drug effects
Lymphangioma, Cystic
/ genetics
Lymphatic Vessels
/ metabolism
Male
Mice
Mice, Knockout
Receptor, Platelet-Derived Growth Factor beta
/ genetics
Vascular Endothelial Growth Factor C
/ metabolism
Vascular Endothelial Growth Factor D
Amphiregulin
PDGFRβ CKO
cystic lymphangioma
lymphangiogeneis
pathogenesis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
entrez:
4
5
2021
pubmed:
5
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C). However, the key signals and cell types that stimulate pathological lymphangiogenesis, such as human cystic lymphangioma, are less well known. Here, we found that mouse dermal fibroblasts that infiltrate to sponges subcutaneously implanted express VEGF-D and sushi, Von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) in response to PDGFRβ signal. In vitro,
Identifiants
pubmed: 33941693
pii: 2019580118
doi: 10.1073/pnas.2019580118
pmc: PMC8126796
pii:
doi:
Substances chimiques
AREG protein, human
0
Amphiregulin
0
Areg protein, mouse
0
Vascular Endothelial Growth Factor C
0
Vascular Endothelial Growth Factor D
0
Vegfd protein, mouse
0
Receptor, Platelet-Derived Growth Factor beta
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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