DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.

Animals Cell Line Crystallography, X-Ray DNA (Cytosine-5-)-Methyltransferase 1 / metabolism DNA Methylation / genetics Genome / genetics Genomic Instability / genetics Heterochromatin / genetics Histones / metabolism Long Interspersed Nucleotide Elements / genetics Mice

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 05 2021
Historique:
received: 23 12 2020
accepted: 15 03 2021
entrez: 4 5 2021
pubmed: 5 5 2021
medline: 21 5 2021
Statut: epublish

Résumé

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA methyltransferase 1 (DNMT1) specifically 'recognizes' H4K20me3 via its first bromo-adjacent-homology domain (DNMT1

Identifiants

DOI: 10.1038/s41467-021-22665-4 PMID: 33941775 PMC: PMC8093215
pubmed: 33941775
doi: 10.1038/s41467-021-22665-4
pii: 10.1038/s41467-021-22665-4
pmc: PMC8093215
doi:

Substances chimiques

Heterochromatin 0
Histones 0
DNA (Cytosine-5-)-Methyltransferase 1 EC 2.1.1.37
Dnmt1 protein, mouse EC 2.1.1.37

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2490

Subventions

Organisme : NCI NIH HHS
ID : T32 CA009302
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM139569
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM111858
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126900
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009156
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119721
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES031707
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211336
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215284
Pays : United States

Références

Biophys J. 2008 Mar 1;94(5):1826-35
pubmed: 17921203
Sci Rep. 2019 Apr 18;9(1):6265
pubmed: 31000785
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9055-9
pubmed: 21518897
Nat Genet. 2020 Aug;52(8):828-839
pubmed: 32690947
Bioinformatics. 2011 Jun 1;27(11):1571-2
pubmed: 21493656
Nucleic Acids Res. 2014 Apr;42(8):e69
pubmed: 24561809
PLoS One. 2009 Aug 26;4(8):e6789
pubmed: 19956676
Nat Rev Genet. 2009 Nov;10(11):805-11
pubmed: 19789556
Mutat Res. 2009 Jun 1;665(1-2):20-8
pubmed: 19427507
Nat Genet. 2005 Apr;37(4):391-400
pubmed: 15765097
Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5
pubmed: 27079975
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Cancer Cell. 2016 Jul 11;30(1):92-107
pubmed: 27344947
J Am Chem Soc. 2004 Mar 10;126(9):2670-1
pubmed: 14995162
Cell. 2002 Feb 22;108(4):489-500
pubmed: 11909520
Hum Mol Genet. 2010 Dec 1;19(23):4634-42
pubmed: 20843831
Nat Rev Genet. 2019 Jul;20(7):417-431
pubmed: 30867571
Cell. 1992 Jun 12;69(6):915-26
pubmed: 1606615
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):664-9
pubmed: 24379388
Mol Cell. 2017 Oct 19;68(2):350-360.e7
pubmed: 29053958
Epigenetics Chromatin. 2017 Feb 23;10:8
pubmed: 28250819
Gerontology. 2014;60(3):197-203
pubmed: 24603298
Nat Genet. 2020 Dec;52(12):1384-1396
pubmed: 33139953
Methods Enzymol. 1997;276:307-26
pubmed: 27754618
Chembiochem. 2014 Mar 21;15(5):743-8
pubmed: 24532244
Nat Clin Pract Oncol. 2005 Dec;2 Suppl 1:S4-11
pubmed: 16341240
EMBO Rep. 2011 Dec 23;13(1):60-7
pubmed: 22056817
Elife. 2016 Sep 06;5:
pubmed: 27595565
Nucleic Acids Res. 2005 Dec 02;33(21):6823-36
pubmed: 16326863
Nature. 2004 Sep 2;431(7004):96-9
pubmed: 15318244
Nature. 2010 Apr 8;464(7290):927-31
pubmed: 20164836
Nature. 1983 Jan 6;301(5895):89-92
pubmed: 6185846
Biochemistry. 2005 Nov 15;44(45):14977-88
pubmed: 16274244
Nature. 2013 Oct 10;502(7470):249-53
pubmed: 24013172
Epigenetics. 2006 Apr-Jun;1(2):63-6
pubmed: 17965604
Hum Mol Genet. 1992 Sep;1(6):397-400
pubmed: 1301913
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18439-18447
pubmed: 32675241
Nature. 2012 Mar 07;484(7392):115-9
pubmed: 22398447
Cell. 2013 Aug 1;154(3):518-29
pubmed: 23911319
Mol Cell. 2014 Jul 17;55(2):277-90
pubmed: 24981170
Nature. 2018 Feb 15;554(7692):387-391
pubmed: 29414941
Science. 2003 Apr 18;300(5618):455
pubmed: 12702868
Genome Biol. 2012 Oct 03;13(10):R87
pubmed: 23034086
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Nature. 2016 Jun 30;534(7609):714-718
pubmed: 27338793
Cell. 1992 Nov 27;71(5):865-73
pubmed: 1423634
Nat Chem Biol. 2017 Mar;13(3):317-324
pubmed: 28114273
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Mol Cell. 2015 Oct 15;60(2):319-27
pubmed: 26439302
J Biol Chem. 2018 Dec 14;293(50):19466-19475
pubmed: 30341171
Cell. 2019 Oct 31;179(4):953-963.e11
pubmed: 31675501
Nat Genet. 2018 Sep;50(9):1247-1253
pubmed: 30082787
Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54
pubmed: 12393927
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Nat Genet. 2018 Sep;50(9):1254-1261
pubmed: 30082786
ACS Chem Biol. 2019 Oct 18;14(10):2315-2326
pubmed: 31479228
Science. 2011 Feb 25;331(6020):1036-40
pubmed: 21163962
Nat Commun. 2020 Mar 6;11(1):1222
pubmed: 32144273
Nat Struct Mol Biol. 2007 Nov;14(11):1025-1040
pubmed: 17984965
Nature. 2016 Apr 21;532(7599):329-33
pubmed: 27027282
Science. 2012 Feb 10;335(6069):709-12
pubmed: 22323818
Epigenetics Chromatin. 2017 Mar 14;10:12
pubmed: 28293301
Mol Cell. 2013 Feb 7;49(3):571-82
pubmed: 23273982
Methods. 2014 Dec;70(2-3):134-8
pubmed: 25063569
Nucleic Acids Res. 1998 Feb 15;26(4):1038-45
pubmed: 9461465
J Mol Biol. 2015 Jul 31;427(15):2520-2531
pubmed: 26070743
Cell. 1992 Jul 10;70(1):5-8
pubmed: 1377983
Nat Commun. 2020 Jul 3;11(1):3355
pubmed: 32620778
Neuropsychopharmacology. 2013 Jan;38(1):138-66
pubmed: 22948975
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
Cold Spring Harb Perspect Biol. 2014 Aug 01;6(8):
pubmed: 25085914
Cell. 2015 Sep 24;163(1):230-45
pubmed: 26365490
J Biol Chem. 2011 Apr 29;286(17):15344-51
pubmed: 21389349
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11614-11623
pubmed: 32393638
Crit Rev Biochem Mol Biol. 2013 May-Jun;48(3):211-21
pubmed: 23181513
J Biol Chem. 2014 Jan 3;289(1):379-86
pubmed: 24253042
Annu Rev Biochem. 2005;74:481-514
pubmed: 15952895
Cell. 2003 May 30;113(5):643-55
pubmed: 12787505
Cell Res. 2015 Aug;25(8):911-29
pubmed: 26065575

Auteurs

Wendan Ren (W)

Department of Biochemistry, University of California, Riverside, CA, USA.

Huitao Fan (H)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Sara A Grimm (SA)

Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
ORCID: 0000-0003-3050-1909

Jae Jin Kim (JJ)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.

Linhui Li (L)

Department of Biochemistry, University of California, Riverside, CA, USA.

Yiran Guo (Y)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
ORCID: 0000-0002-6266-9186

Christopher James Petell (CJ)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Xiao-Feng Tan (XF)

Department of Biochemistry, University of California, Riverside, CA, USA.

Zhi-Min Zhang (ZM)

Department of Biochemistry, University of California, Riverside, CA, USA.
ORCID: 0000-0002-5088-5869

John P Coan (JP)

Department of Biology, Stanford University, Stanford, CA, USA.

Jiekai Yin (J)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.

Dae In Kim (DI)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.

Linfeng Gao (L)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
ORCID: 0000-0001-6194-5145

Ling Cai (L)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Nelli Khudaverdyan (N)

Department of Biochemistry, University of California, Riverside, CA, USA.

Burak Çetin (B)

Cell, Molecular, and Developmental Biology Graduate Program, University of California, Riverside, Riverside, CA, USA.

Dinshaw J Patel (DJ)

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-9779-7778

Yinsheng Wang (Y)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
Department of Chemistry, University of California, Riverside, CA, USA.

Qiang Cui (Q)

Departments of Chemistry, Physics and Biomedical Engineering, Boston University, Boston, MA, USA.

Brian D Strahl (BD)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
ORCID: 0000-0002-4947-6259

Or Gozani (O)

Department of Biology, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-1365-4463

Kyle M Miller (KM)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.
ORCID: 0000-0002-4544-0013

Seán E O'Leary (SE)

Department of Biochemistry, University of California, Riverside, CA, USA.
Cell, Molecular, and Developmental Biology Graduate Program, University of California, Riverside, Riverside, CA, USA.

Paul A Wade (PA)

Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
ORCID: 0000-0002-6042-357X

Gang Greg Wang (GG)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg_wang@med.unc.edu.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg_wang@med.unc.edu.
ORCID: 0000-0002-7210-9940

Jikui Song (J)

Department of Biochemistry, University of California, Riverside, CA, USA. jikui.song@ucr.edu.
Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. jikui.song@ucr.edu.
ORCID: 0000-0002-4958-1032

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA (Cytosine-5-)-methyltransferase 1 › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Hétérochromatine › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Rétroéléments › Éléments LINE › DNMT1 reads heterochromatic H4K20me3 to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › DNMT1 reads heterochromatic H4K20me3 to...