Clinical outcomes in patients with Philadelphia chromosome-positive leukemia treated with ponatinib in routine clinical practice-data from a Belgian registry.
Adult
Aged
Aged, 80 and over
Antineoplastic Agents
/ adverse effects
Belgium
Cardiovascular Diseases
/ chemically induced
Drug Eruptions
/ etiology
Drug Substitution
Female
Follow-Up Studies
Fusion Proteins, bcr-abl
/ antagonists & inhibitors
Humans
Ichthyosis
/ chemically induced
Imidazoles
/ adverse effects
Kaplan-Meier Estimate
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Progression-Free Survival
Prospective Studies
Protein Kinase Inhibitors
/ adverse effects
Pyridazines
/ adverse effects
Registries
Salvage Therapy
Treatment Outcome
Young Adult
Chronic myeloid leukemia
Philadelphia chromosome-positive acute lymphoblastic leukemia
Ponatinib
Registry
Routine clinical practice
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
28
07
2020
accepted:
03
04
2021
pubmed:
5
5
2021
medline:
22
6
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
Data on clinical use of ponatinib are limited. This prospective registry aimed to evaluate outcomes of ponatinib treatment in routine practice over 3 years (2016-2019) in Belgium (NCT03678454). Patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) were treated with ponatinib per current label. Fifty patients (33 CML and 17 Ph+ ALL) were enrolled. Fifty-five percent of CML and 29% of Ph+ ALL patients had received ≥3 prior tyrosine kinase inhibitors (TKIs). Reasons for starting ponatinib were intolerance (40%), relapse or refractoriness (28%) to previous TKIs, progression (16%), or T315I mutation (16%). Median follow-up was 15 months for CML and 4.5 months for Ph+ ALL patients. Best response was a major molecular response in 58% of CML and 41% of Ph+ ALL patients. Of 20 patients who started ponatinib due to intolerance to previous TKIs, 9 (64%) CML and 4 (67%) Ph+ ALL achieved a major molecular response. Three-year estimates of overall survival were 85.3% and 85.6%, respectively, in CML and Ph+ ALL patients; estimated progression-free survival was 81.6% and 48.9%. Adverse reactions were reported in 34 patients (68%); rash (26%) and dry skin (10%) were most common. Reported cardiovascular adverse reactions included vascular stenosis (3), arterial hypertension (2), chest pain (1), palpitations (1), and vascular occlusion (1). This Belgian registry confirms results from the PACE clinical trial and supports routine ponatinib use in CML and Ph+ ALL patients who are resistant or intolerant to previous TKIs or with the T315I mutation.
Identifiants
pubmed: 33942128
doi: 10.1007/s00277-021-04507-x
pii: 10.1007/s00277-021-04507-x
pmc: PMC8195783
doi:
Substances chimiques
Antineoplastic Agents
0
Imidazoles
0
Protein Kinase Inhibitors
0
Pyridazines
0
ponatinib
4340891KFS
Fusion Proteins, bcr-abl
EC 2.7.10.2
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1723-1732Subventions
Organisme : Incyte Biosciences Benelux BV
ID : Not applicable
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