A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection.
COVID-19
antiviral agents
bronchiolitis obliterans
corticosteroids
treatment
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
15
04
2021
received:
03
03
2021
accepted:
15
04
2021
pubmed:
5
5
2021
medline:
25
6
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
During the COVID-19 pandemic, management of SARS-CoV-2 infection in children with underlying chronic lung disease has been challenging. There are limited studies in children with respiratory comorbidities, apart from asthma, presumably due to low morbidity of SARS-CoV-2 infection in the general pediatric population along with the low incidence of certain pulmonary conditions. Compassionate use of remdesivir has been shown to reduce time to clinical improvement in adults and has been retrospectively studied in small pediatric cohorts with promising results. Whether children with underlying respiratory conditions may benefit from antiviral treatment in the context of different pathophysiologic backgrounds and unknown drug safety and efficacy needs to be further evaluated. We present a case of COVID-19 infection in a 3-year old toddler with severe postinfectious bronchiolitis obliterans, who received compassionate treatment with 5-day-course of remdesivir, and recovered with favourable outcome.
Identifiants
pubmed: 33945679
doi: 10.1002/ppul.25436
pmc: PMC8242384
doi:
Substances chimiques
Antiviral Agents
0
Adenosine Monophosphate
415SHH325A
Alanine
OF5P57N2ZX
Types de publication
Letter
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2381-2384Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Eur J Pediatr. 2021 Apr;180(4):1317-1322
pubmed: 33200304
ERJ Open Res. 2020 Oct 26;6(4):
pubmed: 33263054
J Pediatric Infect Dis Soc. 2020 Dec 31;9(6):701-715
pubmed: 32318706
Lancet Child Adolesc Health. 2020 Sep;4(9):653-661
pubmed: 32593339
Clin Immunol. 2020 Oct;219:108550
pubmed: 32745524