Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage.
Animals
Animals, Newborn
Cells, Cultured
Cerebral Cortex
/ diagnostic imaging
Cerebral Intraventricular Hemorrhage
/ diagnostic imaging
Cognitive Dysfunction
/ diagnostic imaging
Excitatory Postsynaptic Potentials
/ physiology
Humans
Inhibitory Postsynaptic Potentials
/ physiology
Magnetic Resonance Imaging
/ methods
Male
Mesenchymal Stem Cell Transplantation
/ methods
Neuronal Plasticity
/ physiology
Rats
Rats, Sprague-Dawley
Thalamus
/ diagnostic imaging
Barrel cortex
Functional MRI (fMRI)
Intraventricular hemorrhage
Mesenchymal stem cell
Sensory-guided decision making
Thalamocortical input
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
11
11
2020
revised:
07
04
2021
accepted:
29
04
2021
pubmed:
5
5
2021
medline:
12
10
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.
Identifiants
pubmed: 33945790
pii: S0014-4886(21)00142-4
doi: 10.1016/j.expneurol.2021.113736
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113736Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.