Lipid metabolism in cancer: New perspectives and emerging mechanisms.
cancer
immunometabolism
lipids
metabolism
metastasis
tumor microenvironment
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
17 05 2021
17 05 2021
Historique:
received:
19
01
2021
revised:
15
03
2021
accepted:
08
04
2021
pubmed:
5
5
2021
medline:
30
9
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. As such, targeting lipid metabolism for anti-cancer therapies is attractive, with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. Here, we discuss these topics and identify open questions.
Identifiants
pubmed: 33945792
pii: S1534-5807(21)00322-1
doi: 10.1016/j.devcel.2021.04.013
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1363-1393Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests S.-M.F. has received funding from Bayer AG, Merck and Black Belt Therapeutics and has consulted for Fund +. All other authors declare no competing interests.