Clofibric acid increases molecular species of phosphatidylethanolamine containing arachidonic acid for biogenesis of peroxisomal membranes in peroxisome proliferation in the liver.
Arachidonic acid
Clofibric acid
Liver
Molecular species
Peroxisomes
Phosphatidylethanolamine
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
19
02
2021
revised:
22
04
2021
accepted:
28
04
2021
pubmed:
5
5
2021
medline:
16
9
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
The biogenesis of peroxisomes in relation to the trafficking of proteins to peroxisomes has been extensively examined. However, the supply of phospholipids, which is needed to generate peroxisomal membranes in mammals, remains unclear. Therefore, we herein investigated metabolic alterations induced by clofibric acid, a peroxisome proliferator, in the synthesis of phospholipids, particularly phosphatidylethanolamine (PE) molecular species, and their relationship with the biogenesis of peroxisomal membranes. The subcutaneous administration of clofibric acid to rats at a relatively low dose (130 mg/kg) once a day time-dependently and gradually increased the integrated perimeter of peroxisomes per 100 μm
Identifiants
pubmed: 33945875
pii: S1388-1981(21)00091-3
doi: 10.1016/j.bbalip.2021.158963
pii:
doi:
Substances chimiques
Phosphatidylethanolamines
0
Arachidonic Acid
27YG812J1I
phosphatidylethanolamine
39382-08-6
Clofibric Acid
53PF01Q249
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158963Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.