Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo IIα.
Antineoplastic Agents
/ chemical synthesis
Benzoxazoles
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
DNA Topoisomerases, Type II
Dose-Response Relationship, Drug
Drug Discovery
Drug Screening Assays, Antitumor
Humans
Models, Molecular
Molecular Structure
Oxazoles
/ chemical synthesis
Pyrimidines
/ chemical synthesis
Structure-Activity Relationship
Topoisomerase II Inhibitors
/ chemical synthesis
Antitumor
Benzoxazoles
Molecular docking
Molecular dynamic simulation
Oxazolo[4,5-b]pyridines
Topoisomerase I and IIα inhibition
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
06
12
2020
revised:
11
03
2021
accepted:
11
04
2021
pubmed:
5
5
2021
medline:
25
2
2023
entrez:
4
5
2021
Statut:
ppublish
Résumé
Discovery of novel anticancer drugs which have low toxicity and high activity is very significant area in anticancer drug research and development. One of the important targets for cancer treatment research is topoisomerase enzymes. In order to make a contribution to this field, we have designed and synthesized some 5(or 6)-nitro-2-(substitutedphenyl)benzoxazole (1a-1r) and 2-(substitutedphenyl)oxazolo[4,5-b]pyridine (2a-2i) derivatives as novel candidate antitumor agents targeting human DNA topoisomerase enzymes (hTopo I and hTopo IIα). Biological activity results were found very promising for the future due to two compounds, 5-nitro-2-(4-butylphenyl)benzoxazole (1i) and 2-(4-butylphenyl)oxazolo[4,5-b]pyridine (2i), that inhibited hTopo IIα with 2 µM IC
Identifiants
pubmed: 33945950
pii: S0045-2068(21)00290-X
doi: 10.1016/j.bioorg.2021.104913
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzoxazoles
0
Oxazoles
0
Pyrimidines
0
Topoisomerase II Inhibitors
0
oxazolo(5,4-d)pyrimidine
0
DNA Topoisomerases, Type II
EC 5.99.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104913Informations de copyright
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