No alteration of leukocyte telomere length in first episode psychosis.
First episode psychosis (FEP)
Schizophrenia
Telomere
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
11
01
2021
accepted:
12
04
2021
pubmed:
5
5
2021
medline:
15
10
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
Both shorter telomeres and schizophrenia have been associated with a decrease in life expectancy. Furthermore, several studies found a shorter telomere length (TL) in schizophrenia. Understanding whether or not telomere shortening is directly related to pathophysiology of schizophrenia or is a consequence of a cumulative exposure to chronic stress is of major importance. Comparing the TL of subjects at the very beginning of the disease (FEP) and control subjects could help to decide between these two hypotheses. The aim of the present study was to compare TL between FEP subjects (N=91) and controls (N=137). After accounting for multiple potential confounders, no significant association was observed between FEP and TL. Our result is consistent with the hypothesis that psycho-social stress / adversities and stressful situations in people with schizophrenia affect TL rather than that telomere erosion contributes to the development of this disorder.
Identifiants
pubmed: 33945962
pii: S0165-1781(21)00238-9
doi: 10.1016/j.psychres.2021.113941
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113941Informations de copyright
Copyright © 2021. Published by Elsevier B.V.