Molecular Mechanism of Thymidylate Synthase Inhibition by N
N4-hydroxy-dCMP binding
dihydrofolate production
imidazolidine ring opening
thymidylate synthase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
04
04
2021
revised:
27
04
2021
accepted:
29
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N
Identifiants
pubmed: 33946210
pii: ijms22094758
doi: 10.3390/ijms22094758
pmc: PMC8125507
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Deoxycytidine Monophosphate
1032-65-1
N-4-hydroxy-2'-deoxycytidylic acid
2277-58-9
Thymidylate Synthase
EC 2.1.1.45
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center, Poland
ID : 2016/21/B/NZ1/00288
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