Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine.
cerebellar ataxias
cerebellar reserve
long-term depression
synaptic plasticity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
12
04
2021
revised:
28
04
2021
accepted:
28
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
The cerebellum is endowed with the capacity for compensation and restoration after pathological injury, a property known as cerebellar reserve. Such capacity is attributed to two unique morphological and physiological features of the cerebellum. First, mossy fibers that convey peripheral and central information run mediolaterally over a wide area of the cerebellum, resulting in the innervation of multiple microzones, commonly known as cerebellar functional units. Thus, a single microzone receives redundant information that can be used in pathological conditions. Secondly, the circuitry is characterized by a co-operative interplay among various forms of synaptic plasticity. Recent progress in understanding the mechanisms of redundant information and synaptic plasticity has allowed outlining therapeutic strategies potentiating these neural substrates to enhance the cerebellar reserve, taking advantage of the unique physiological properties of the cerebellum which appears as a modular and potentially reconfiguring brain structure.
Identifiants
pubmed: 33946358
pii: ijms22094777
doi: 10.3390/ijms22094777
pmc: PMC8124536
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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