Isolation and Proteomics of the Insulin Secretory Granule.
beta-cells
granule protein purification
insulin secretory granule
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
12
04
2021
revised:
28
04
2021
accepted:
28
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
6
5
2021
Statut:
epublish
Résumé
Insulin, a vital hormone for glucose homeostasis is produced by pancreatic beta-cells and when secreted, stimulates the uptake and storage of glucose from the blood. In the pancreas, insulin is stored in vesicles termed insulin secretory granules (ISGs). In Type 2 diabetes (T2D), defects in insulin action results in peripheral insulin resistance and beta-cell compensation, ultimately leading to dysfunctional ISG production and secretion. ISGs are functionally dynamic and many proteins present either on the membrane or in the lumen of the ISG may modulate and affect different stages of ISG trafficking and secretion. Previously, studies have identified few ISG proteins and more recently, proteomics analyses of purified ISGs have uncovered potential novel ISG proteins. This review summarizes the proteins identified in the current ISG proteomes from rat insulinoma INS-1 and INS-1E cell lines. Here, we also discuss techniques of ISG isolation and purification, its challenges and potential future directions.
Identifiants
pubmed: 33946444
pii: metabo11050288
doi: 10.3390/metabo11050288
pmc: PMC8147143
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Prog Nucleic Acid Res Mol Biol. 1999;63:69-108
pubmed: 10506829
Mol Biol Cell. 2000 Dec;11(12):4079-91
pubmed: 11102509
J Proteome Res. 2007 Aug;6(8):2978-92
pubmed: 17583932
Biophys Rep. 2018;4(6):329-338
pubmed: 30596141
Cell Metab. 2018 Feb 6;27(2):470-478.e4
pubmed: 29414688
Annu Rev Cell Dev Biol. 2000;16:19-49
pubmed: 11031229
Biometals. 2005 Aug;18(4):295-303
pubmed: 16158220
Biol Cell. 2006 May;98(5):307-15
pubmed: 16441241
Am J Med. 2003 Apr 15;114(6):438-44
pubmed: 12727576
Sci Rep. 2015 Sep 02;5:13681
pubmed: 26330153
Methods Mol Biol. 2017;1546:177-185
pubmed: 27896767
Diabetologia. 1982 Oct;23(4):365-73
pubmed: 6292032
Regul Pept. 2008 Nov 29;151(1-3):19-25
pubmed: 18722481
Diabetes Obes Metab. 2012 Oct;14 Suppl 3:129-35
pubmed: 22928573
Biochem J. 1987 Jun 1;244(2):457-64
pubmed: 2822006
J Diabetes Res. 2015;2015:549818
pubmed: 26064985
Proteomics. 2010 Nov;10(22):3935-56
pubmed: 21080488
Mol Cell Proteomics. 2007 Jun;6(6):1007-17
pubmed: 17317658
Cell. 1985 Sep;42(2):671-81
pubmed: 3896518
Diabetes. 1999 Sep;48(9):1686-90
pubmed: 10480595
J Proteome Res. 2009 Jan;8(1):178-86
pubmed: 19055480
J Proteomics. 2012 Aug 3;75(15):4620-31
pubmed: 22569486
Cell Metab. 2010 Aug 4;12(2):117-29
pubmed: 20674857
Histochemistry. 1987;87(2):99-106
pubmed: 3305433
PLoS One. 2014 Oct 13;9(10):e109082
pubmed: 25310693
J Cell Biol. 1998 Apr 20;141(2):359-71
pubmed: 9548715
Clin Proteomics. 2020 May 24;17:17
pubmed: 32489335
Diabetes Obes Metab. 2017 Sep;19 Suppl 1:115-123
pubmed: 28880475
Histochem Cell Biol. 2020 Apr;153(4):279-285
pubmed: 31901974
J Cell Biol. 2005 Oct 10;171(1):99-109
pubmed: 16216924
J Biol Chem. 2020 Jul 3;295(27):8901-8911
pubmed: 32341128
J Physiol. 2004 Jun 15;557(Pt 3):935-48
pubmed: 15090611
Diabetologia. 2014 Feb;57(2):362-5
pubmed: 24233056
Mol Biol Cell. 2010 Jan 1;21(1):87-94
pubmed: 19889833
Biomark Med. 2015;9(3):259-65
pubmed: 25731211
Adv Exp Med Biol. 2010;654:305-38
pubmed: 20217504
J Cell Sci. 2005 Dec 15;118(Pt 24):5873-84
pubmed: 16317050
J Biol Chem. 1992 Jul 25;267(21):15229-36
pubmed: 1634553
Diabetologia. 2013 Feb;56(2):359-69
pubmed: 23132338
J Cell Biol. 1986 Dec;103(6 Pt 1):2273-81
pubmed: 3536964
Physiol Rev. 2018 Jan 1;98(1):117-214
pubmed: 29212789
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28307-28315
pubmed: 33122440
J Cell Biol. 1991 Dec;115(6):1491-503
pubmed: 1757459
Hum Mol Genet. 2013 Jan 15;22(2):203-17
pubmed: 23035048
Cell Death Dis. 2015 Mar 12;6:e1684
pubmed: 25766323
Mol Endocrinol. 2007 Sep;21(9):2255-69
pubmed: 17579214
Pflugers Arch. 2002 May;444(1-2):43-51
pubmed: 11976915
Leukemia. 2002 Mar;16(3):376-81
pubmed: 11896541
Biochem Biophys Res Commun. 1983 Jul 29;114(2):835-42
pubmed: 6349638
Diabetes. 2013 Jul;62(7):2416-28
pubmed: 23423569
Science. 1977 Jun 17;196(4296):1313-9
pubmed: 325648
Nat Commun. 2019 Jul 25;10(1):3312
pubmed: 31346174
Data Brief. 2015 Mar 10;3:234-9
pubmed: 26217750
Diabetologia. 2016 Jul;59(7):1480-1491
pubmed: 26831301
J Histochem Cytochem. 2001 Apr;49(4):519-28
pubmed: 11259455
Nature. 1988 May 5;333(6168):93-6
pubmed: 3283564
J Neurochem. 1998 Jan;70(1):374-83
pubmed: 9422384
Diabetes. 2013 Nov;62(11):3687-96
pubmed: 23929935
J Biol Chem. 1984 May 25;259(10):6041-4
pubmed: 6327660
J Clin Invest. 2021 Jan 19;131(2):
pubmed: 33463547
Diabetologia. 2003 Aug;46(8):1029-45
pubmed: 12879249
Endocrinology. 1991 Aug;129(2):734-40
pubmed: 1855471
EBioMedicine. 2017 Feb;16:262-274
pubmed: 28163042
Mol Cell Endocrinol. 2007 Jan 29;264(1-2):90-101
pubmed: 17092635
Mol Endocrinol. 2004 Jan;18(1):117-26
pubmed: 14593078
Diabetes Obes Metab. 2017 Sep;19 Suppl 1:107-114
pubmed: 28880479
Traffic. 2004 Jan;5(1):53-61
pubmed: 14675425
Nat Biotechnol. 2018 Oct 22;:
pubmed: 30346938
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3865-9
pubmed: 3287379
Cell. 1979 Oct;18(2):545-58
pubmed: 498284
Diabetologia. 1994 Sep;37 Suppl 2:S48-56
pubmed: 7821740
Diabetes. 2021 Feb;70(2):436-448
pubmed: 33168621
Gene. 2019 Jul 20;706:52-61
pubmed: 31039435
Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E805-E819
pubmed: 31479304
Commun Integr Biol. 2013 Mar 1;6(2):e23098
pubmed: 23749176
Biochem J. 1998 Jun 15;332 ( Pt 3):593-610
pubmed: 9620860
Diabetes Care. 2016 Nov;39(11):2080-2088
pubmed: 27926891
Biochim Biophys Acta. 1998 Aug 14;1404(1-2):101-12
pubmed: 9714762
J Cell Sci. 2019 Jul 1;132(13):
pubmed: 31182646
J Cell Biol. 1997 May 5;137(3):595-608
pubmed: 9151667
Mol Cells. 2003 Dec 31;16(3):323-30
pubmed: 14744022
Cell Rep. 2013 Sep 12;4(5):921-30
pubmed: 24012759
ISRN Endocrinol. 2012;2012:834359
pubmed: 23119181
J Biol Chem. 1998 Nov 20;273(47):31180-5
pubmed: 9813022
Endocrinology. 1998 Nov;139(11):4714-25
pubmed: 9794484
Trends Endocrinol Metab. 2014 Aug;25(8):381-8
pubmed: 24746186
J Endocrinol. 2005 Apr;185(1):57-67
pubmed: 15817827
Cell. 2001 Aug 24;106(4):499-509
pubmed: 11525735
Mol Aspects Med. 2015 Apr;42:105-18
pubmed: 25579745
J Biol Chem. 2015 Apr 24;290(17):11075-92
pubmed: 25762724
Diabetes. 2004 Sep;53(9):2330-7
pubmed: 15331542
Cytometry A. 2008 Jul;73(7):615-25
pubmed: 18412218
J Cell Sci. 2001 Jun;114(Pt 11):2145-54
pubmed: 11493650
J Biol Chem. 2007 Apr 27;282(17):12717-24
pubmed: 17289672
Cancer Lett. 2018 Nov 28;437:79-88
pubmed: 30165196
Mol Biol Cell. 2018 Nov 1;29(22):2700-2708
pubmed: 30156474
Exp Diabetes Res. 2008;2008:165360
pubmed: 18670618
EMBO Rep. 2014 Jun;15(6):714-22
pubmed: 24711543
Sci Rep. 2016 Apr 01;6:23909
pubmed: 27032672
Proteomics. 2008 Sep;8(18):3848-61
pubmed: 18704904
PLoS Biol. 2013;11(4):e1001541
pubmed: 23630453
Mol Endocrinol. 2006 Aug;20(8):1935-47
pubmed: 16556729
FEBS Lett. 1995 Mar 6;360(3):294-8
pubmed: 7883050
Annu Rev Biomed Eng. 2009;11:49-79
pubmed: 19400705
Pflugers Arch. 2009 Apr;457(6):1343-50
pubmed: 18795319
Biophys Rep. 2015;1:34-40
pubmed: 26942217
J Cell Biol. 1984 Jan;98(1):222-8
pubmed: 6368567
J Clin Invest. 2014 Oct;124(10):4240-56
pubmed: 25157818
Sci Adv. 2020 Jan 10;6(2):eaax8978
pubmed: 31950079
J Cell Sci. 2009 Apr 1;122(Pt 7):893-903
pubmed: 19295123
EMBO J. 1995 Jun 15;14(12):2723-30
pubmed: 7796801
Regul Pept. 1999 Sep 15;83(2-3):123-7
pubmed: 10511466
PLoS One. 2012;7(10):e47921
pubmed: 23133529
Sci Rep. 2019 Feb 27;9(1):2890
pubmed: 30814595
Diabetologia. 2008 Jun;51(6):997-1007
pubmed: 18437352
Cell. 1987 Jun 19;49(6):865-8
pubmed: 3555846
Elife. 2017 Jul 04;6:
pubmed: 28673385
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7432-6
pubmed: 19372374
Diabetes. 2019 Apr;68(4):747-760
pubmed: 30670477
J Biol Chem. 1996 Jul 26;271(30):18161-70
pubmed: 8663434
Hum Mol Genet. 2011 Apr 1;20(7):1274-84
pubmed: 21199859
J Clin Endocrinol Metab. 2016 Mar;101(3):1044-54
pubmed: 26713822
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E667-76
pubmed: 25646459
Elife. 2020 Nov 09;9:
pubmed: 33164744
Mol Cell Endocrinol. 2021 Jan 15;520:111076
pubmed: 33159991
Anal Biochem. 1987 Oct;166(1):142-9
pubmed: 3314586
PLoS One. 2010 Jan 28;5(1):e8936
pubmed: 20126668
Biochem J. 1987 Sep 1;246(2):279-86
pubmed: 3318807
J Proteomics. 2015 Mar 18;117:156-67
pubmed: 25638021
Biochem J. 1987 Jul 15;245(2):575-82
pubmed: 2822027
Hum Genomics Proteomics. 2009 Dec 08;2009:
pubmed: 20948568
Cell Rep. 2017 Sep 5;20(10):2480-2489
pubmed: 28877479
Diabetes. 2013 Jun;62(6):2004-14
pubmed: 23349488