Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes.
antioxidant
bile acids
electron paramagnetic resonance
lipid peroxidation
liposome
photoreceptor membrane
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
29 Apr 2021
29 Apr 2021
Historique:
received:
08
03
2021
revised:
25
04
2021
accepted:
27
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
6
5
2021
Statut:
epublish
Résumé
Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid containing taurine conjugated with the ursodeoxycholic acid (UDCA), has been known and used from ancient times as a therapeutic compound in traditional Chinese medicine. TUDCA has recently been gaining significant interest as a neuroprotective agent, also exploited in the visual disorders. Among several mechanisms of TUDCA's protective action, its antioxidant activity and stabilizing effect on mitochondrial and plasma membranes are considered. In this work we investigated antioxidant activity of TUDCA and its impact on structural properties of model membranes of different composition using electron paramagnetic resonance spectroscopy and the spin labeling technique. Localization of TUDCA molecules in a pure POPC bilayer has been studied using a molecular dynamics simulation (MD). The obtained results indicate that TUDCA is not an efficient singlet oxygen (
Identifiants
pubmed: 33946822
pii: membranes11050327
doi: 10.3390/membranes11050327
pmc: PMC8146903
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : 35p/11/2017, URL: https://app.dimensions.ai/details/grant/grant.7424462
Références
Trends Mol Med. 2008 Feb;14(2):54-62
pubmed: 18218342
J Lipid Res. 1993 Nov;34(11):1911-7
pubmed: 8263415
Hepatology. 2002 Sep;36(3):592-601
pubmed: 12198651
Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jun;143(2):204-8
pubmed: 16571381
Eur J Neurol. 2016 Jan;23(1):11-2
pubmed: 25828295
J Biophotonics. 2014 Sep;7(9):744-56
pubmed: 24604883
Invest Ophthalmol Vis Sci. 2008 May;49(5):2148-55
pubmed: 18436848
PLoS One. 2012;7(4):e35102
pubmed: 22496896
Biophys J. 2016 Sep 6;111(5):999-1007
pubmed: 27602727
J Photochem Photobiol B. 2001 Nov 15;64(2-3):144-61
pubmed: 11744401
J Neurochem. 2008 Jan;104(2):336-52
pubmed: 17944869
Mol Neurobiol. 2017 Oct;54(8):6107-6119
pubmed: 27699602
Cell Biochem Biophys. 2020 Jun;78(2):139-147
pubmed: 32236880
Free Radic Biol Med. 2006 Oct 15;41(8):1257-65
pubmed: 17015172
J Membr Biol. 1974;15(2):159-92
pubmed: 4366085
Free Radic Biol Med. 2006 May 15;40(10):1820-6
pubmed: 16678020
Mol Vis. 2006 Dec 29;12:1706-14
pubmed: 17213800
Biochemistry. 1978 Aug 8;17(16):3310-5
pubmed: 687586
Photochem Photobiol. 1994 Mar;59(3):284-9
pubmed: 8016206
Biomolecules. 2018 Nov 27;8(4):
pubmed: 30486474
J Comput Chem. 2010 Mar;31(4):671-90
pubmed: 19575467
Vision Res. 1998 May;38(10):1325-33
pubmed: 9667000
Acta Biochim Pol. 2012;59(1):119-24
pubmed: 22428148
Gastroenterology. 1994 May;106(5):1333-41
pubmed: 8174892
Exp Eye Res. 2018 May;170:51-57
pubmed: 29454859
J Lipid Res. 2009 Sep;50(9):1721-34
pubmed: 19417220
Phys Rev A Gen Phys. 1985 Mar;31(3):1695-1697
pubmed: 9895674
Cell Biochem Biophys. 2017 Dec;75(3-4):443-454
pubmed: 29098642
Free Radic Biol Med. 2011 Apr 1;50(7):892-8
pubmed: 21236336
Anal Chem. 2019 Aug 6;91(15):9867-9874
pubmed: 31241915
Neuron. 2005 Nov 3;48(3):387-401
pubmed: 16269358
Biochem Pharmacol. 2002 Dec 1;64(11):1661-7
pubmed: 12429355
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6
pubmed: 12149470
Int J Mol Sci. 2020 Aug 20;21(17):
pubmed: 32825239
J Biol Chem. 1995 Aug 11;270(32):18825-30
pubmed: 7642534
Mol Med Rep. 2014 Nov;10(5):2255-62
pubmed: 25201602
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Adv Exp Med Biol. 1998;442:163-8
pubmed: 9635028
Dose Response. 2018 Jul 18;16(3):1559325818782631
pubmed: 30038553
Biomater Sci. 2019 Aug 1;7(8):3178-3189
pubmed: 31143889
Biochem Biophys Res Commun. 2011 Jun 17;409(4):610-5
pubmed: 21605547
Biochemistry. 1990 May 1;29(17):4059-69
pubmed: 2163271
Glob Adv Health Med. 2014 May;3(3):58-69
pubmed: 24891994
J Neurochem. 2000 Dec;75(6):2368-79
pubmed: 11080188
Sci Rep. 2017 Jun 19;7(1):3831
pubmed: 28630443
Biochim Biophys Acta. 1998 Jan 19;1368(2):235-46
pubmed: 9459601
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Biochem Biophys Res Commun. 2001 Feb 23;281(2):468-74
pubmed: 11181071
Mol Neurobiol. 2012 Oct;46(2):475-86
pubmed: 22773138
Invest Ophthalmol Vis Sci. 2012 Jun 05;53(7):3349-56
pubmed: 22531707
Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165972
pubmed: 32949768
Biophys J. 2002 Mar;82(3):1469-82
pubmed: 11867462
Photochem Photobiol. 1999 Oct;70(4):391-475
pubmed: 10546544
Biomedicines. 2020 Sep 21;8(9):
pubmed: 32967221
Biochim Biophys Acta. 1986 Jan 29;854(2):307-17
pubmed: 3002470
Antioxidants (Basel). 2020 Oct 31;9(11):
pubmed: 33142756
Biochim Biophys Acta. 2013 Sep;1828(9):2152-63
pubmed: 23747364
Cell Biochem Biophys. 2017 Dec;75(3-4):433-442
pubmed: 28413858
Langmuir. 2011 Jun 7;27(11):6950-61
pubmed: 21568285
J Exp Biol. 1997 Dec;200(Pt 23):2927-36
pubmed: 9359876
J Ethnobiol Ethnomed. 2009 Jan 12;5:2
pubmed: 19138420
Front Med (Lausanne). 2017 Oct 03;4:163
pubmed: 29043249
Photochem Photobiol. 2001 Jan;73(1):71-6
pubmed: 11202369
Photochem Photobiol Sci. 2009 Jun;8(6):830-7
pubmed: 19492111
Photochem Photobiol. 2012 Nov-Dec;88(6):1309-19
pubmed: 22428905
Chem Sci. 2018 Jul 31;9(34):6935-6943
pubmed: 30258563
Exp Neurol. 2017 Sep;295:77-87
pubmed: 28552716
World J Gastroenterol. 2005 Aug 21;11(31):4875-8
pubmed: 16097062
Sci Rep. 2017 Aug 21;7(1):8945
pubmed: 28827720
J Biol Chem. 1989 May 15;264(14):8151-5
pubmed: 2722776
Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G129-39
pubmed: 24852569
Biochem Mol Biol Int. 1997 Apr;41(4):687-94
pubmed: 9111930
Nat Genet. 2002 Oct;32(2):254-60
pubmed: 12219089
Arch Biochem Biophys. 1990 Jan;276(1):19-25
pubmed: 2297222
J Cell Biol. 2015 Nov 9;211(3):495-502
pubmed: 26527746
FEBS Lett. 1979 Dec 1;108(1):152-4
pubmed: 520538
Analyst. 2016 Sep 21;141(18):5329-38
pubmed: 27332112
Sci Rep. 2019 Oct 29;9(1):15475
pubmed: 31664105
Invest Ophthalmol Vis Sci. 2012 Jan 05;53(1):100-6
pubmed: 22110077
Photochem Photobiol. 2005 Nov-Dec;81(6):1305-30
pubmed: 16120006
Int J Mol Sci. 2021 Mar 06;22(5):
pubmed: 33800818
Photochem Photobiol. 1988 Sep;48(3):271-6
pubmed: 3222336
J Neurochem. 2011 Jan;116(1):144-53
pubmed: 21054389
Biophys J. 2000 Nov;79(5):2632-43
pubmed: 11053136
Biochemistry. 1994 Jun 21;33(24):7670-81
pubmed: 8011634
J Comput Chem. 2013 Sep 30;34(25):2135-45
pubmed: 23832629
Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4728-33
pubmed: 16303972
Photochem Photobiol. 2006 Sep-Oct;82(5):1161-77
pubmed: 16683906
Pharmacol Rep. 2010 Jan-Feb;62(1):185-93
pubmed: 20360629
Free Radic Biol Med. 1998 May;24(7-8):1107-12
pubmed: 9626564
Chem Soc Rev. 2010 Aug;39(8):3181-209
pubmed: 20571680
Biophys J. 2003 Aug;85(2):1248-58
pubmed: 12885668