Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H
Antioxidants
/ pharmacology
Apoptosis Regulatory Proteins
/ biosynthesis
Catalase
/ biosynthesis
Cell Line
Cytochromes c
/ biosynthesis
Drug Evaluation, Preclinical
Epithelial Cells
/ drug effects
Gene Expression Regulation
/ drug effects
Glutathione
/ biosynthesis
Glutathione Peroxidase
/ biosynthesis
Humans
Hydrogen Peroxide
/ toxicity
Lutein
/ analogs & derivatives
MAP Kinase Signaling System
/ drug effects
Macular Degeneration
/ drug therapy
Molecular Structure
Oxidative Stress
/ drug effects
Prodrugs
/ pharmacology
Reactive Oxygen Species
/ metabolism
Retinal Pigment Epithelium
/ cytology
age-related macular degeneration
human retinal pigmented epithelium
lutein
lutein diglutaric acid
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Apr 2021
29 Apr 2021
Historique:
received:
07
04
2021
revised:
26
04
2021
accepted:
26
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Oxidative stress-induced cell damage and death of the retinal pigmented epithelium (RPE), a polarized monolayer that maintains retinal health and homeostasis, lead to the development of age-related macular degeneration (AMD). Several studies show that the naturally occurring antioxidant Lutein (Lut) can protect RPE cells from oxidative stress. However, the poor solubility and low oral bioavailability limit the potential of Lut as a therapeutic agent. In this study, lutein diglutaric acid (Lut-DG), a prodrug of Lut, was synthesized and its ability to protect human ARPE-19 cells from oxidative stress was tested compared to Lut. Both Lut and Lut-DG significantly decreased H
Identifiants
pubmed: 33946898
pii: ijms22094722
doi: 10.3390/ijms22094722
pmc: PMC8125252
pii:
doi:
Substances chimiques
Antioxidants
0
Apoptosis Regulatory Proteins
0
Prodrugs
0
Reactive Oxygen Species
0
Cytochromes c
9007-43-6
Hydrogen Peroxide
BBX060AN9V
CAT protein, human
EC 1.11.1.6
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Glutathione
GAN16C9B8O
Lutein
X72A60C9MT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ratchadaphiseksomphot Endowment Fund for the Natural Products for Ageing and Chronic Diseases, Chulalongkorn University
ID : Pornchai Rojsitthisak
Organisme : the Thailand Science Research and Innovation (TSRI) Fund
ID : CU_FRB640001_01_33_3
Organisme : The authors express gratitude to the National Research Council of Thailand
ID : IRN FY2020 507/2563 (P.R.)
Références
Int J Mol Sci. 2010 May 11;11(5):2109-17
pubmed: 20559505
J Cell Mol Med. 2013 Jan;17(1):103-15
pubmed: 23205553
Oncogene. 2004 Apr 12;23(16):2838-49
pubmed: 15077147
Biogerontology. 2013 Oct;14(5):461-82
pubmed: 24057278
Trends Cell Biol. 2000 Dec;10(12):524-30
pubmed: 11121744
Sci Rep. 2016 Jul 22;6:30226
pubmed: 27444056
Nutrients. 2013 Apr 09;5(4):1169-85
pubmed: 23571649
Free Radic Biol Med. 2010 Apr 15;48(8):1064-70
pubmed: 20100568
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5168-77
pubmed: 17962470
J Ophthalmol. 2016;2016:2913612
pubmed: 27563459
Prog Retin Eye Res. 2017 Sep;60:201-218
pubmed: 28336424
Mol Med Rep. 2017 Aug;16(2):2069-2074
pubmed: 28656238
Oxid Med Cell Longev. 2018 Nov 21;2018:1610751
pubmed: 30584457
Nat Rev Genet. 2020 Dec;21(12):769-781
pubmed: 32601318
Traffic. 2004 Nov;5(11):884-95
pubmed: 15479453
Antioxidants (Basel). 2020 Sep 06;9(9):
pubmed: 32899990
Food Funct. 2013 Feb;4(2):338-46
pubmed: 23175101
Pharmacol Rep. 2006 May-Jun;58(3):353-63
pubmed: 16845209
Arch Toxicol. 2015 Jul;89(7):1103-17
pubmed: 25138434
Immunobiology. 2012 Feb;217(2):127-46
pubmed: 21868123
Oxid Med Cell Longev. 2016;2016:8479718
pubmed: 28101299
Eur J Med Chem. 2017 Feb 15;127:810-827
pubmed: 27823878
Front Pharmacol. 2018 Nov 05;9:1280
pubmed: 30455645
Biochem Biophys Res Commun. 2005 Sep 30;335(3):949-56
pubmed: 16105664
J Agric Food Chem. 2017 Jul 26;65(29):5944-5952
pubmed: 28665123
Int J Mol Sci. 2020 Mar 28;21(7):
pubmed: 32231094
Nat Rev Drug Discov. 2008 Mar;7(3):255-70
pubmed: 18219308
BMC Ophthalmol. 2003 Mar 21;3:5
pubmed: 12659653
Biosci Biotechnol Biochem. 1999;63(10):1784-6
pubmed: 26300170
Mol Aspects Med. 2001 Aug-Oct;22(4-5):217-46
pubmed: 11679167
Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):341-353
pubmed: 27683187
Sci Rep. 2019 Aug 12;9(1):11718
pubmed: 31406217
PLoS One. 2016 Dec 9;11(12):e0167828
pubmed: 27936094
Int J Biochem Cell Biol. 2004 Dec;36(12):2519-30
pubmed: 15325589
Curr Opin Ophthalmol. 2020 May;31(3):215-221
pubmed: 32205470
Foods. 2021 Feb 26;10(3):
pubmed: 33652594
Antioxidants (Basel). 2020 Jun 09;9(6):
pubmed: 32526968
Mol Vis. 2006 Sep 30;12:1127-35
pubmed: 17093397
Eur J Pharmacol. 2016 Jan 5;770:1-8
pubmed: 26643168
Mol Vis. 2011;17:3180-90
pubmed: 22194644
J Biol Chem. 2009 May 15;284(20):13291-5
pubmed: 19182219
Biomolecules. 2019 Aug 19;9(8):
pubmed: 31430968
Biosci Biotechnol Biochem. 2018 Aug;82(8):1301-1308
pubmed: 29678124
Lancet Glob Health. 2014 Feb;2(2):e106-16
pubmed: 25104651
Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34
pubmed: 11033038
Biomed Pharmacother. 2017 Apr;88:124-133
pubmed: 28103505
Arch Ophthalmol. 2010 Jun;128(6):750-8
pubmed: 20547953
Neuron. 2012 Jul 12;75(1):26-39
pubmed: 22794258
Methods Enzymol. 2002;348:182-90
pubmed: 11885271
Oxid Med Cell Longev. 2017;2017:8416763
pubmed: 28819546
Arch Ophthalmol. 1991 Sep;109(9):1285-8
pubmed: 1929958
Am J Physiol Renal Physiol. 2007 Jan;292(1):F440-7
pubmed: 16885155
Food Funct. 2015 Feb;6(2):450-60
pubmed: 25469663
Trials. 2020 Jan 6;21(1):32
pubmed: 31907080
Int J Mol Sci. 2020 Aug 09;21(16):
pubmed: 32784830
Mol Aspects Med. 2012 Aug;33(4):295-317
pubmed: 22542780
J Cell Mol Med. 2013 Jul;17(7):833-43
pubmed: 23663427
Cell Death Discov. 2017 Jul 03;3:17025
pubmed: 28690874
J Recept Signal Transduct Res. 2015;35(6):600-4
pubmed: 26096166
Pharmaceutics. 2019 Aug 01;11(8):
pubmed: 31374932
Int J Mol Sci. 2019 Jul 09;20(13):
pubmed: 31323999
Invest Ophthalmol Vis Sci. 2002 Sep;43(9):3091-8
pubmed: 12202534
J Appl Toxicol. 2005 Sep-Oct;25(5):374-82
pubmed: 16013042
World Allergy Organ J. 2012 Jan;5(1):9-19
pubmed: 23268465
Int J Oncol. 2018 Jun;52(6):2119-2129
pubmed: 29620169
Carbohydr Polym. 2021 Mar 15;256:117426
pubmed: 33483016
BMC Pharmacol Toxicol. 2021 Jan 20;22(1):7
pubmed: 33472699