Rapid Spread of the SARS-CoV-2 Variant of Concern 202012/01 in Southern Italy (December 2020-March 2021).
COVID-19
Italy
VOC 202012/01-B.1.1.7 lineage SARS-CoV-2
surveillance
variants of concern
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
29 Apr 2021
29 Apr 2021
Historique:
received:
29
03
2021
revised:
28
04
2021
accepted:
28
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
11
5
2021
Statut:
epublish
Résumé
Epidemiological and virological studies have revealed that SARS-CoV-2 variants of concern (VOCs) are emerging globally, including in Europe. The aim of this study was to evaluate the spread of B.1.1.7-lineage SARS-CoV-2 in southern Italy from December 2020-March 2021 through the detection of the S gene target failure (SGTF), which could be considered a robust proxy of VOC B.1.1.7. SGTF was assessed on 3075 samples from week 52/2020 to week 10/2021. A subset of positive samples identified in the Apulia region during the study period was subjected to whole-genome sequencing (WGS). A descriptive and statistical analysis of the demographic and clinical characteristics of cases according to SGTF status was performed. Overall, 20.2% of samples showed SGTF; 155 strains were confirmed as VOC 202012/01 by WGS. The proportion of SGTF-positive samples rapidly increased over time, reaching 69.2% in week 10/2021. SGTF-positive cases were more likely to be symptomatic and to result in hospitalization (
Identifiants
pubmed: 33947087
pii: ijerph18094766
doi: 10.3390/ijerph18094766
pmc: PMC8125211
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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