Diagnosis of Pseudoprogression Following Lomustine-Temozolomide Chemoradiation in Newly Diagnosed Glioblastoma Patients Using FET-PET.
Adult
Aged
Antineoplastic Agents, Alkylating
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Brain Neoplasms
/ diagnostic imaging
Chemoradiotherapy
Disease Progression
Female
Glioblastoma
/ diagnostic imaging
Humans
Lomustine
/ administration & dosage
Male
Middle Aged
Positron-Emission Tomography
/ methods
Retrospective Studies
Temozolomide
/ administration & dosage
Tyrosine
/ analogs & derivatives
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
04
02
2021
revised:
15
03
2021
accepted:
28
04
2021
pubmed:
6
5
2021
medline:
2
4
2022
entrez:
5
5
2021
Statut:
ppublish
Résumé
The CeTeG/NOA-09 phase III trial demonstrated a significant survival benefit of lomustine-temozolomide chemoradiation in patients with newly diagnosed glioblastoma with methylated O We retrospectively identified patients (i) who were treated off-study according to the CeTeG/NOA-09 protocol, (ii) had equivocal MRI findings after radiotherapy, and (iii) underwent additional FET-PET imaging for diagnostic evaluation (number of scans, 1-3). Maximum and mean tumor-to-brain ratios (TBR We identified 23 patients with 32 FET-PET scans. Within 5-25 weeks after radiotherapy (median time, 9 weeks), pseudoprogression occurred in 11 patients (48%). The parameter TBR The data suggest that FET-PET parameters are of significant clinical value to diagnose pseudoprogression related to lomustine-temozolomide chemoradiation.
Identifiants
pubmed: 33947699
pii: 1078-0432.CCR-21-0471
doi: 10.1158/1078-0432.CCR-21-0471
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
O-(2-fluoroethyl)tyrosine
0
Tyrosine
42HK56048U
Lomustine
7BRF0Z81KG
Temozolomide
YF1K15M17Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3704-3713Informations de copyright
©2021 American Association for Cancer Research.
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